The effects of cantharidin analogues on xanthine oxidase

Wei Tsauer, Jaung Geng Lin, Pen Yuan Lin, Feng Lin Hsu, Hsuch Ching Chiang

Research output: Contribution to journalArticlepeer-review

44 Citations (Scopus)


Norcantharidin, the demethylated product of cantharidin has been used for the treatment of hepatoma, carcinomas of esophagus and gastric cardia, leukopenia and hepatitis. Since the enzyme xanthine oxidase is involved in the diseases mentioned above, and the reactive oxygen species produced by the enzyme induces DNA damage and oxidative damage of tissues, fourteen cantharidin analogues and cantharidimide derivatives were tested for their effects on xanthine oxidase. The results showed that these compounds displayed very weak inhibitory effects on xanthine oxidase. Contrary to expectation disodium cantharidate, Norcantharidin, dehydronorcantharidin, disodium dehydronorcantharidate, N-(2-pyridyl) cantharidimide, N-(3-pyridyl) cantharidimide and N-(4-pyridyl) cantharidimide showed a slight stimulating effect on xanthine oxidase at several concentrations.

Original languageEnglish
Pages (from-to)2095-2098
Number of pages4
JournalAnticancer Research
Issue number3 C
Publication statusPublished - 1997


  • Cantharidin and cantharidimide analogues
  • Toxic substances
  • Xanthine oxidase stimulants

ASJC Scopus subject areas

  • Cancer Research
  • Oncology


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