The effect of moderate endurance training on cardioprotective molecule adaptations

Zong Yan Cai, Cheng Chen Hsu, Mei Chich Hsu, Mao Shung Huang, Chao Pin Yang, Yung Yu Tsai, Borcherng Su

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)


Purpose: This study aimed to investigate the effect of moderate endurance training on cardio-protective molecule adaptations, including marker of stem cell activation in the myocardium. Materials and Methods: Twenty-four Spra-gue-Dawley rats were randomly divided into a 4-wk exercise training (4WT) group, a 4-wk sedentary control (4WC) group, an 8-wk exercise training (8WT) group, and an 8-wk sedentary control (8WC) group (n=6 respectively). The training protocol consisted of treadmill running at 20 m/ min for 30 min on a 0% grade, for 3 days/wk. Immunohistochemistry staining coupled with image analysis, as expressed by mean optical density, was used for protein quantification.Results: The results indicated that the heat shock protein (HSP70) and stem cell marker, as evaluated by c-kit, were higher in 4WT than those in the 4WC and 8WT group (p < 0.05), and the HSP70 content in the 8WT was higher than that of the 8WC group. In addition, 4WT and 8WT groups exhibited a significantly higher hepatocyte growth factor (HGF) and c-met content compared to their respective control counterparts (p <0.05).Conclusions: This study suggests that training-induced stem cell activation in the myocardium corresponds with the cardioprotective molecular markers in the early stage of training, and thenthe activated stem cells in the myocardium might subject to a withdrawal before the remodeling events have completed. Additionally, training induced upregulation of cardiomyocyte HGF/c-met signaling pathway may participate in a more long lasting mechanism of exercise training-induced cardioprotection.

Original languageEnglish
Pages (from-to)1912-1920
Number of pages9
Issue number6 SUPPL. 1
Publication statusPublished - 2011


  • C-kit
  • C-met
  • HGF
  • HSP70

ASJC Scopus subject areas

  • General Medicine


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