The Effect of Long COVID-19 Infection and Vaccination on Male Fertility; A Narrative Review

Soheila Pourmasumi; Alireza Nazari; Zahra Ahmadi; Sophia N. Kouni; Cesare de Gregorio; Ioanna Koniari; Periklis Dousdampanis; Virginia Mplani; Panagiotis Plotas; Stelios Assimakopoulos; Christos Gogos; Georgios Aidonisdis; Pavlos Roditis; Nikos Matsas; Dimitrios Velissaris; Gianfranco Calogiuri; Ming Yow Hung; Servet Altay; Nicholas G. Kounis

doi:10.3390/vaccines10121982

The Effect of Long COVID-19 Infection and Vaccination on Male Fertility; A Narrative Review

Soheila Pourmasumi, Alireza Nazari, Zahra Ahmadi, Sophia N. Kouni, Cesare de Gregorio, Ioanna Koniari, Periklis Dousdampanis, Virginia Mplani, Panagiotis Plotas, Stelios Assimakopoulos, Christos Gogos, Georgios Aidonisdis, Pavlos Roditis, Nikos Matsas, Dimitrios Velissaris, Gianfranco Calogiuri, Ming Yow Hung, Servet Altay, Nicholas G. Kounis

Research output: Contribution to journal › Review article › peer-review

10 Citations (Scopus)

Abstract

Earlier research has suggested that the male reproductive system could be particularly vulnerable to SARS-CoV-2 (COVID-19) infection, and infections involving this novel disease not only pose serious health threats but could also cause male infertility. Data from multi-organ research during the recent outbreak indicate that male infertility might not be diagnosed as a possible consequence of COVID-19 infection. Several review papers have summarized the etiology factors on male fertility, but to date no review paper has been published defining the effect of COVID-19 infection on male fertility. Therefore, the aim of this study is to review the published scientific evidence regarding male fertility potential, the risk of infertility during the COVID-19 pandemic, and the impact of COVID-19 vaccination on the male reproductive system. The effects of COVID-19 infection and the subsequent vaccination on seminal fluid, sperm count, sperm motility, sperm morphology, sperm viability, testes and sex hormones are particularly reviewed.

Original language	English
Article number	1982
Journal	Vaccines
Volume	10
Issue number	12
DOIs	https://doi.org/10.3390/vaccines10121982
Publication status	Published - Dec 2022

Keywords

COVID-19
infertility
SARS
sperm
vaccine

ASJC Scopus subject areas

Immunology
Pharmacology
Drug Discovery
Infectious Diseases
Pharmacology (medical)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3390/vaccines10121982

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Pourmasumi, S., Nazari, A., Ahmadi, Z., Kouni, S. N., de Gregorio, C., Koniari, I., Dousdampanis, P., Mplani, V., Plotas, P., Assimakopoulos, S., Gogos, C., Aidonisdis, G., Roditis, P., Matsas, N., Velissaris, D., Calogiuri, G., Hung, M. Y., Altay, S., & Kounis, N. G. (2022). The Effect of Long COVID-19 Infection and Vaccination on Male Fertility; A Narrative Review. Vaccines, 10(12), Article 1982. https://doi.org/10.3390/vaccines10121982

Pourmasumi, S, Nazari, A, Ahmadi, Z, Kouni, SN, de Gregorio, C, Koniari, I, Dousdampanis, P, Mplani, V, Plotas, P, Assimakopoulos, S, Gogos, C, Aidonisdis, G, Roditis, P, Matsas, N, Velissaris, D, Calogiuri, G, Hung, MY, Altay, S & Kounis, NG 2022, 'The Effect of Long COVID-19 Infection and Vaccination on Male Fertility; A Narrative Review', Vaccines, vol. 10, no. 12, 1982. https://doi.org/10.3390/vaccines10121982

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abstract = "Earlier research has suggested that the male reproductive system could be particularly vulnerable to SARS-CoV-2 (COVID-19) infection, and infections involving this novel disease not only pose serious health threats but could also cause male infertility. Data from multi-organ research during the recent outbreak indicate that male infertility might not be diagnosed as a possible consequence of COVID-19 infection. Several review papers have summarized the etiology factors on male fertility, but to date no review paper has been published defining the effect of COVID-19 infection on male fertility. Therefore, the aim of this study is to review the published scientific evidence regarding male fertility potential, the risk of infertility during the COVID-19 pandemic, and the impact of COVID-19 vaccination on the male reproductive system. The effects of COVID-19 infection and the subsequent vaccination on seminal fluid, sperm count, sperm motility, sperm morphology, sperm viability, testes and sex hormones are particularly reviewed.",

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AB - Earlier research has suggested that the male reproductive system could be particularly vulnerable to SARS-CoV-2 (COVID-19) infection, and infections involving this novel disease not only pose serious health threats but could also cause male infertility. Data from multi-organ research during the recent outbreak indicate that male infertility might not be diagnosed as a possible consequence of COVID-19 infection. Several review papers have summarized the etiology factors on male fertility, but to date no review paper has been published defining the effect of COVID-19 infection on male fertility. Therefore, the aim of this study is to review the published scientific evidence regarding male fertility potential, the risk of infertility during the COVID-19 pandemic, and the impact of COVID-19 vaccination on the male reproductive system. The effects of COVID-19 infection and the subsequent vaccination on seminal fluid, sperm count, sperm motility, sperm morphology, sperm viability, testes and sex hormones are particularly reviewed.

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The Effect of Long COVID-19 Infection and Vaccination on Male Fertility; A Narrative Review

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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