TY - JOUR
T1 - The effect of combined steroid and calcium channel blocker injection on human hypertrophic scars in animal model
T2 - A new strategy for the treatment of hypertrophic scars
AU - Yang, Jui Yung
AU - Huang, Chun Yuan
PY - 2010/12
Y1 - 2010/12
N2 - Background Hypertrophic scars (HScs) are inelastic scars that can cause functional loss and disfigurement. Decorin regulates collagen fibrillogenesis, and its expression is lower in HScs than in normal skin and during wound healing. Objective To evaluate the efficacy of combined verapamil and triamcinolone in treating HScs. Methods Excised human HSc fragments from surgically treated burned patients were divided into three groups: A (normal saline), B (verapamil), and C (verapamil and triamcinolone). The specimens were bilaterally implanted in the back of nude mice, treated using intralesional injections, and observed for 4 weeks. We compared the fibroblast viability and proliferation, decorin staining, and scar weights to evaluate treatment efficacy. Results Viability and proliferation of HSc fibroblasts from groups B and C were significantly lower at all time intervals after transplantation (p
AB - Background Hypertrophic scars (HScs) are inelastic scars that can cause functional loss and disfigurement. Decorin regulates collagen fibrillogenesis, and its expression is lower in HScs than in normal skin and during wound healing. Objective To evaluate the efficacy of combined verapamil and triamcinolone in treating HScs. Methods Excised human HSc fragments from surgically treated burned patients were divided into three groups: A (normal saline), B (verapamil), and C (verapamil and triamcinolone). The specimens were bilaterally implanted in the back of nude mice, treated using intralesional injections, and observed for 4 weeks. We compared the fibroblast viability and proliferation, decorin staining, and scar weights to evaluate treatment efficacy. Results Viability and proliferation of HSc fibroblasts from groups B and C were significantly lower at all time intervals after transplantation (p
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U2 - 10.1111/j.1524-4725.2010.01759.x
DO - 10.1111/j.1524-4725.2010.01759.x
M3 - Article
C2 - 20973868
AN - SCOPUS:78649985814
SN - 1076-0512
VL - 36
SP - 1942
EP - 1949
JO - Dermatologic Surgery
JF - Dermatologic Surgery
IS - 12
ER -