Abstract
In this study, a water-soluble chitosan derivative, N,O- carboxymethylchitosan (NOCC) has been synthesized. Hyaluronic acid (HA) could evolve into a better cross-linked hydrogel by conjugating with NOCC, using carbodiimide as a cross-linker, therefore decreased the swelling capability and increased the resistance against hyaluronidase degradation of the HA-based hydrogels. The NOCC/HA mixed solution, after reacting with carbodiimide, increased its viscosity instantously and formed a hydrogel having a relatively low degree of swelling and high resistance against hyaluronidase. An injectable bone cement composed of nanocrystalline hydroxyapatite (HAp) and crosslinked NOCC/HA were developed by directly blending apatites with the NOCC/HA mixed solution, followed by crosslinked with carbodiimide. The mechanical strength of the NOCC/HA hydrogels were tuned by varying the apatite loading and NOCC/HA mixed ratio. These results indicated that the nanocrystalline HAp reinforced NOCC/HA composites make them attractive for as an injectable bone cement.
| Original language | English |
|---|---|
| Title of host publication | 7th Asian-Australasian Conference on Composite Materials 2010, ACCM 2010 |
| Publisher | ACCM-7 Organizing Committee |
| Pages | 967-970 |
| Number of pages | 4 |
| Volume | 2 |
| ISBN (Print) | 9781632660756 |
| Publication status | Published - 2010 |
| Externally published | Yes |
| Event | 7th Asian-Australasian Conference on Composite Materials 2010, ACCM 2010 - Taipei, Taiwan Duration: Nov 15 2010 → Nov 18 2010 |
Other
| Other | 7th Asian-Australasian Conference on Composite Materials 2010, ACCM 2010 |
|---|---|
| Country/Territory | Taiwan |
| City | Taipei |
| Period | 11/15/10 → 11/18/10 |
Keywords
- Chitosan
- Hyaluronic acid
- Hydroxyapatite
- Thermal stability
ASJC Scopus subject areas
- Electronic, Optical and Magnetic Materials