@inproceedings{9f7fc476bb704777b41408b2329ad224,
title = "The development of a nanocrystalline apatite reinforced crosslinked hyaluronic acid-N,O-carboxymethylchitosan (NOCC) composite as an injectable bone cement",
abstract = "In this study, a water-soluble chitosan derivative, N,O- carboxymethylchitosan (NOCC) has been synthesized. Hyaluronic acid (HA) could evolve into a better cross-linked hydrogel by conjugating with NOCC, using carbodiimide as a cross-linker, therefore decreased the swelling capability and increased the resistance against hyaluronidase degradation of the HA-based hydrogels. The NOCC/HA mixed solution, after reacting with carbodiimide, increased its viscosity instantously and formed a hydrogel having a relatively low degree of swelling and high resistance against hyaluronidase. An injectable bone cement composed of nanocrystalline hydroxyapatite (HAp) and crosslinked NOCC/HA were developed by directly blending apatites with the NOCC/HA mixed solution, followed by crosslinked with carbodiimide. The mechanical strength of the NOCC/HA hydrogels were tuned by varying the apatite loading and NOCC/HA mixed ratio. These results indicated that the nanocrystalline HAp reinforced NOCC/HA composites make them attractive for as an injectable bone cement.",
keywords = "Chitosan, Hyaluronic acid, Hydroxyapatite, Thermal stability",
author = "Mi, {Fwu Long} and Yu, {Shu Huei} and Tang, {Deh Wei} and Hsieh, {Hao Ying} and Kuo, {Tzu Hung} and Wang, {Wei Ren}",
year = "2010",
language = "English",
isbn = "9781632660756",
series = "7th Asian-Australasian Conference on Composite Materials 2010, ACCM 2010",
publisher = "ACCM-7 Organizing Committee",
pages = "967--970",
booktitle = "7th Asian-Australasian Conference on Composite Materials 2010, ACCM 2010",
note = "7th Asian-Australasian Conference on Composite Materials 2010, ACCM 2010 ; Conference date: 15-11-2010 Through 18-11-2010",
}