TY - JOUR
T1 - The correlation between fatty liver disease and chronic kidney disease
AU - Chen, Po Chun
AU - Kao, Wei Yu
AU - Cheng, Yuan Lung
AU - Wang, Yuan Jen
AU - Hou, Ming Chih
AU - Wu, Jaw Ching
AU - Su, Chien Wei
N1 - Funding Information:
This study was supported by grants from Ministry of Science and Technology of Taiwan ( MOST 106-2314-B-075-043 ) and Taipei Veterans General Hospital ( 107VACS-003 and V107E-004-1 ).
PY - 2020/1
Y1 - 2020/1
N2 - Background/purpose: The impact of non-alcoholic fatty liver disease (NAFLD) on the prevalence of chronic kidney disease (CKD) is not fully elucidated. We aimed to assess the correlation between NAFLD and CKD in a large population study. Methods: We included consecutive subjects who had received health check-up service at Taipei Veterans General Hospital from 2002 to 2009. NAFLD was diagnosed with abdominal ultrasound, and advanced liver fibrosis was determined with NAFLD fibrosis score (NAFLD-FS). CKD was defined as estimated glomerular filtration rate (eGFR) < 60 mL/min/1.73 m 2 . Results: Among the 29,797 subjects enrolled in this study, NAFLD and CKD were diagnosed in 44.5% and 20.2% of the population, respectively. Subjects with NAFLD had a higher proportion of CKD compared to those without NAFLD (24.1% vs. 17.1%, p < 0.001). However, NAFLD was not related to CKD with an odds ratio (OR) of 1.015 (95% confidence interval [CI] 0.954–1.081, p = 0.630) after multivariate analyses. Nevertheless, further analyses revealed that among patients with NAFLD, those with advanced fibrosis were more likely to have CKD after adjusting for confounding factors (OR 2.284, 95% CI 1.513–3.448, p < 0.001). Conclusion: NAFLD per se was not a risk factor for CKD, but NAFLD patients with advanced fibrosis faced a higher possibility of CKD. Hence, patients with NAFLD and advanced fibrosis should be screened for CKD and prompted to receive treatment if the diagnosis was made.
AB - Background/purpose: The impact of non-alcoholic fatty liver disease (NAFLD) on the prevalence of chronic kidney disease (CKD) is not fully elucidated. We aimed to assess the correlation between NAFLD and CKD in a large population study. Methods: We included consecutive subjects who had received health check-up service at Taipei Veterans General Hospital from 2002 to 2009. NAFLD was diagnosed with abdominal ultrasound, and advanced liver fibrosis was determined with NAFLD fibrosis score (NAFLD-FS). CKD was defined as estimated glomerular filtration rate (eGFR) < 60 mL/min/1.73 m 2 . Results: Among the 29,797 subjects enrolled in this study, NAFLD and CKD were diagnosed in 44.5% and 20.2% of the population, respectively. Subjects with NAFLD had a higher proportion of CKD compared to those without NAFLD (24.1% vs. 17.1%, p < 0.001). However, NAFLD was not related to CKD with an odds ratio (OR) of 1.015 (95% confidence interval [CI] 0.954–1.081, p = 0.630) after multivariate analyses. Nevertheless, further analyses revealed that among patients with NAFLD, those with advanced fibrosis were more likely to have CKD after adjusting for confounding factors (OR 2.284, 95% CI 1.513–3.448, p < 0.001). Conclusion: NAFLD per se was not a risk factor for CKD, but NAFLD patients with advanced fibrosis faced a higher possibility of CKD. Hence, patients with NAFLD and advanced fibrosis should be screened for CKD and prompted to receive treatment if the diagnosis was made.
KW - Kidney diseases
KW - Liver fibrosis
KW - Non-alcoholic fatty liver disease
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U2 - 10.1016/j.jfma.2019.02.010
DO - 10.1016/j.jfma.2019.02.010
M3 - Article
AN - SCOPUS:85062616136
SN - 0929-6646
VL - 119
SP - 42
EP - 50
JO - Journal of the Formosan Medical Association
JF - Journal of the Formosan Medical Association
IS - 1P1
ER -