Abstract
Purpose: The mechanism of cancer cachexia remains unclear and inflammatory cytokines may play a role in its development. Interleukin-6 (IL-6), C-reactive protein (CRP) and tumor necrosis factor-a (TNFα) are known to be associated with cancer cachexia. Tartrate-resistant acid phos-phatase 5a (TRACP5α) is proposed to be related to chronic inflammation. In this study we hypothesize that TRACP5α is a chronic inflammatory marker that is correlated with cancer cachexia. Methods: Fifty-five cancer patients with and without cancer cachexia were enrolled from January 2009 to December 2012. Body mass index (BMI) was measured and serum total cholesterol, triglycerides and albumin were examined to evaluate the nutritional status. IL-6, CRP and TRACPSα protein activity were evaluated. Results: Inflammatory markers including IL-6, and CRP were significantly elevated in patients with cancer cachexia (ρ=0.0075 and 0.0021, respectively). Patients with cachexia also had higher CRP/albumin ratio (ρ =0.0265). TRACP5α activity, TRACP5α protein and their combinations with albumin were increased in the cancer cachexia groups but without significant difference. There were good correlations between IL-6, CRP, and BMI. Patients with higher TRACP5α activity had shorter survival (ρ=0.004). Conclusion:TRACP5α may be a promising chronic inflammatory marker and may play a prognostic role in cancer cachexia. Further large-scale prospective studies are warranted to confirm its role in the cancer cachexia process.
| Original language | English |
|---|---|
| Pages (from-to) | 325-331 |
| Number of pages | 7 |
| Journal | Journal of B.U.ON. |
| Volume | 20 |
| Issue number | 1 |
| Publication status | Published - Jan 1 2015 |
Keywords
- Cancer cachexia
- Chronic inflammation
- Tartrate-resistant acid phosphatase 5a
ASJC Scopus subject areas
- Hematology
- Oncology
- Radiology Nuclear Medicine and imaging
- Cancer Research
