TY - JOUR
T1 - The biatrial substrate properties in different types of paroxysmal atrial fibrillation
AU - Huang, Shih Yu
AU - Lin, Yenn Jiang
AU - Tsao, Hsuan Ming
AU - Chang, Shih Lin
AU - Lo, Li Wei
AU - Hu, Hu Feng
AU - Suenari, Kazuyoshi
AU - Lin, Yung Kuo
AU - Huang, Jen Hung
AU - Chen, I. Chung
AU - Ko, Wen Chin
AU - Ong, Eng Thiam
AU - Chen, Shih Ann
N1 - Funding Information:
This work was supported by grants of NSC (Taiwan, ROC), Grant No 99-2627-B-008-003, NSC99-2628-B-075-007-MY3 , grants of Taipei Veterans General Hospital ( V99B2-007 ), and grants of Taipei Medical University-Wan Fang Hospital ( 100swf01,100swf06 ).
PY - 2011/7
Y1 - 2011/7
N2 - Background: The biatrial substrate properties in patients with paroxysmal atrial fibrillation (AF) originating from the pulmonary veins (PVs) and superior vena cava (SVC) are not available. Objective: The purpose of this study is to characterize the differences of biatrial substrate properties in patients with different types of AF. Methods: A total of 36 patients with paroxysmal AF originating from the PV (PV-AF) and 9 patients with paroxysmal AF initiating from the SVC (SVC-AF) were included. Regional electrogram voltage, conduction velocity (CV), and spectral analysis to identify the AF nest were performed to characterize the biatrial, PVs, and SVC substrate. Results: In the left atrial (LA) body, the bipolar voltage, total activation time, CV, and dominant frequency (DF) were similar between the PV-AF and SVC-AF. However, in the PV regions, the electrogram voltage, CV, and DF were decreased in the PV-AF. The proportions of AF nest in the LA body (72.2% vs. 22.2%, P = .008) and PV regions (100% vs. 22.2%, P <.001) were higher in PV-AF compared with SVC-AF, respectively. On the other hand, lower bipolar voltage, longer total activation time, and slower CV of RA body were recognized in the SVC-AF as compared with the PV-AF. In the SVC, lower bipolar voltage, slower CV, higher DF, and higher proportions of AF nest in SVC (16.7% vs. 66.7%, P = .002) were identified in SVC-AF. Conclusion: These most-remodeled substrates in different types of paroxysmal AF indicated the importance of the atrial substrate in the vicinity of the arrhythmogenic thoracic veins. Crown
AB - Background: The biatrial substrate properties in patients with paroxysmal atrial fibrillation (AF) originating from the pulmonary veins (PVs) and superior vena cava (SVC) are not available. Objective: The purpose of this study is to characterize the differences of biatrial substrate properties in patients with different types of AF. Methods: A total of 36 patients with paroxysmal AF originating from the PV (PV-AF) and 9 patients with paroxysmal AF initiating from the SVC (SVC-AF) were included. Regional electrogram voltage, conduction velocity (CV), and spectral analysis to identify the AF nest were performed to characterize the biatrial, PVs, and SVC substrate. Results: In the left atrial (LA) body, the bipolar voltage, total activation time, CV, and dominant frequency (DF) were similar between the PV-AF and SVC-AF. However, in the PV regions, the electrogram voltage, CV, and DF were decreased in the PV-AF. The proportions of AF nest in the LA body (72.2% vs. 22.2%, P = .008) and PV regions (100% vs. 22.2%, P <.001) were higher in PV-AF compared with SVC-AF, respectively. On the other hand, lower bipolar voltage, longer total activation time, and slower CV of RA body were recognized in the SVC-AF as compared with the PV-AF. In the SVC, lower bipolar voltage, slower CV, higher DF, and higher proportions of AF nest in SVC (16.7% vs. 66.7%, P = .002) were identified in SVC-AF. Conclusion: These most-remodeled substrates in different types of paroxysmal AF indicated the importance of the atrial substrate in the vicinity of the arrhythmogenic thoracic veins. Crown
KW - Atrial fibrillation
KW - Pulmonary vein
KW - Substrate mapping
KW - Superior vena cava
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U2 - 10.1016/j.hrthm.2011.01.046
DO - 10.1016/j.hrthm.2011.01.046
M3 - Article
C2 - 21315847
AN - SCOPUS:79959947001
SN - 1547-5271
VL - 8
SP - 961
EP - 967
JO - Heart Rhythm
JF - Heart Rhythm
IS - 7
ER -