The beneficial effects of statins in patients undergoing hemodialysis

Jaw Wen Chen, Chin Chou Huang, Wan Leong Chan, Yu Chun Chen, Tzeng Ji Chen, Chia Min Chung, Po Hsun Huang, Shing Jong Lin, Hsin Bang Leu

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)

Abstract

Background The beneficial effects of statins in patients undergoing hemodialysis are controversial. Our study aimed to investigate the use of statins and the subsequent risk of cardiovascular morbidity and mortality in patients undergoing hemodialysis. Methods We conducted a cohort study using data from the Taiwan National Health Insurance Research Database. Cox regressions were performed to determine the hazard ratio (HR) of cardiovascular morbidity and mortality in the HD patients taking statins (statin cohort) compared with a propensity-matched comparison cohort. Results The statin cohort included a total of 4074 patients who received statin treatment while also undergoing hemodialysis (mean age 53.3 ± 13.5 years, male 34.9%). The comparison cohort included 8148 propensity-matched hemodialysis patients who were not using statins. During the three years of follow-up, the statin cohort had lower incidence of ischemic stroke (p < 0.001), hospitalizations due to unstable angina (p < 0.001), deep vein thrombosis (p < 0.001), cardiovascular mortality (p < 0.001), and all-cause mortality (p < 0.001). After Cox regression analysis, statin use was independently associated with lower risk of future ischemic stroke (HR, 0.49; 95% confidence interval [CI], 0.39-0.63), hospitalization for unstable angina (HR, 0.57; 95% CI, 0.47-0.70), deep vein thrombosis (HR, 0.11; 95% CI, 0.05-0.27), cardiovascular mortality (HR, 0.29; 95% CI, 0.18-0.46), and all-cause mortality (HR, 0.49; 95% CI, 0.41-0.58). Conclusion Statin use was associated with a lower incidence of cardiovascular morbidity and mortality in patients undergoing hemodialysis.

Original languageEnglish
Pages (from-to)4155-4159
Number of pages5
JournalInternational Journal of Cardiology
Volume168
Issue number4
DOIs
Publication statusPublished - Oct 9 2013
Externally publishedYes

Keywords

  • Cardiovascular
  • Hemodialysis
  • Morbidity
  • Mortality
  • Statins

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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