TY - JOUR
T1 - The association between serum vitamin D level and risk and prognosis of melanoma
T2 - a systematic review and meta-analysis
AU - Tsai, T. Y.
AU - Kuo, C. Y.
AU - Huang, Y. C.
N1 - © 2020 European Academy of Dermatology and Venereology.
PY - 2020/8/1
Y1 - 2020/8/1
N2 - Background: Vitamin D has antineoplastic effects, but the synthesis of vitamin D requires ultraviolet radiation, a known risk factor for melanoma. Objective: To investigate the correlations between serum vitamin D levels and risk and prognosis of melanoma. Methods: A systematic review and meta-analysis were conducted. Online databases were searched on 31 Oct 2018. Results: Twenty-five studies with a total of 11166 patients with melanoma were included. There was no significant difference in serum vitamin D levels between patients with melanoma and controls [standardized mean difference (SMD), −0.185; 95% confidence interval (CI), −0.533 to 0.162]. However, the prevalence of vitamin D deficiency was significantly higher in patients with melanoma than that in controls (odds ratio, 2.115; 95% CI, 1.151–3.885). In terms of prognosis, serum vitamin D levels were significantly higher in melanoma patients with lower Breslow thickness (≦1 vs. >1 mm: SMD, 0.243; 95% CI, 0.160–0.327). Moreover, melanoma patients with lower vitamin D levels had a significantly higher mortality rate (hazard ratio, 1.558; 95% CI, 1.258–1.931). Conclusions: Vitamin D deficiency is associated with higher Breslow thickness and mortality in melanoma patients.
AB - Background: Vitamin D has antineoplastic effects, but the synthesis of vitamin D requires ultraviolet radiation, a known risk factor for melanoma. Objective: To investigate the correlations between serum vitamin D levels and risk and prognosis of melanoma. Methods: A systematic review and meta-analysis were conducted. Online databases were searched on 31 Oct 2018. Results: Twenty-five studies with a total of 11166 patients with melanoma were included. There was no significant difference in serum vitamin D levels between patients with melanoma and controls [standardized mean difference (SMD), −0.185; 95% confidence interval (CI), −0.533 to 0.162]. However, the prevalence of vitamin D deficiency was significantly higher in patients with melanoma than that in controls (odds ratio, 2.115; 95% CI, 1.151–3.885). In terms of prognosis, serum vitamin D levels were significantly higher in melanoma patients with lower Breslow thickness (≦1 vs. >1 mm: SMD, 0.243; 95% CI, 0.160–0.327). Moreover, melanoma patients with lower vitamin D levels had a significantly higher mortality rate (hazard ratio, 1.558; 95% CI, 1.258–1.931). Conclusions: Vitamin D deficiency is associated with higher Breslow thickness and mortality in melanoma patients.
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U2 - 10.1111/jdv.16189
DO - 10.1111/jdv.16189
M3 - Article
C2 - 31919907
AN - SCOPUS:85079042399
SN - 0926-9959
VL - 34
SP - 1722
EP - 1729
JO - Journal of the European Academy of Dermatology and Venereology
JF - Journal of the European Academy of Dermatology and Venereology
IS - 8
ER -