The association between serum asymmetric dimethylarginine and coronary atherosclerotic plaque in an asymptomatic population

Chun Yao Huang; Jong Shiuan Yeh; Chun Ming Shih; Feng Yen Lin; Yung Ta Kao; Nai Wen Tsao; Wen Tien Hsiao; Jaw Wen Chen; Nen Chung Chang; Kou-Gi Shyu

doi:10.2174/187152212802001848

The association between serum asymmetric dimethylarginine and coronary atherosclerotic plaque in an asymptomatic population

Chun Yao Huang, Jong Shiuan Yeh, Chun Ming Shih, Feng Yen Lin, Yung Ta Kao, Nai Wen Tsao, Wen Tien Hsiao, Jaw Wen Chen, Nen Chung Chang, Kou-Gi Shyu

Research output: Contribution to journal › Article › peer-review

Abstract

Asymmetric dimethylarginine (ADMA) is an endogenous competitive inhibitor of nitric oxide synthase and is independently associated with poor cardiovascular outcomes. However, the direct relationship between serum ADMA level and the extent of subclinical coronary atherosclerotic plaque has never been investigated. In total, 130 consecutive asymptomatic Taiwanese subjects (mean age, 55.6±10 years), who received a health screening evaluation, were enrolled. Coronary plaque detected by computed tomography coronary angiography (CTCA) was observed in 85 (65.4%) of 130 individuals. Patients with coronary plaque had a higher ADMA level (1.16±1.15 μmol/L vs. 0.42 ± 0.33 μmol /L, p

Original language	English
Pages (from-to)	236-243
Number of pages	8
Journal	Immunology, Endocrine and Metabolic Agents in Medicinal Chemistry
Volume	12
Issue number	3
DOIs	https://doi.org/10.2174/187152212802001848
Publication status	Published - 2012

Keywords

Asymmetric dimethylarginine (ADMA)
Asymptomatic
Atherosclerotic plaque
Computed tomography coronary angiography (CTCA)
Coronary atherosclerosis
Endothelial dysfunction
Nitric oxide (NO)

ASJC Scopus subject areas

Endocrinology, Diabetes and Metabolism
Immunology and Allergy
Pharmacology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.2174/187152212802001848

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Huang, C. Y., Yeh, J. S., Shih, C. M., Lin, F. Y., Kao, Y. T., Tsao, N. W., Hsiao, W. T., Chen, J. W., Chang, N. C., & Shyu, K.-G. (2012). The association between serum asymmetric dimethylarginine and coronary atherosclerotic plaque in an asymptomatic population. Immunology, Endocrine and Metabolic Agents in Medicinal Chemistry, 12(3), 236-243. https://doi.org/10.2174/187152212802001848

Huang, CY , Yeh, JS , Shih, CM , Lin, FY , Kao, YT, Tsao, NW, Hsiao, WT, Chen, JW, Chang, NC & Shyu, K-G 2012, 'The association between serum asymmetric dimethylarginine and coronary atherosclerotic plaque in an asymptomatic population', Immunology, Endocrine and Metabolic Agents in Medicinal Chemistry, vol. 12, no. 3, pp. 236-243. https://doi.org/10.2174/187152212802001848

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abstract = "Asymmetric dimethylarginine (ADMA) is an endogenous competitive inhibitor of nitric oxide synthase and is independently associated with poor cardiovascular outcomes. However, the direct relationship between serum ADMA level and the extent of subclinical coronary atherosclerotic plaque has never been investigated. In total, 130 consecutive asymptomatic Taiwanese subjects (mean age, 55.6±10 years), who received a health screening evaluation, were enrolled. Coronary plaque detected by computed tomography coronary angiography (CTCA) was observed in 85 (65.4%) of 130 individuals. Patients with coronary plaque had a higher ADMA level (1.16±1.15 μmol/L vs. 0.42 ± 0.33 μmol /L, p",

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AU - Huang, Chun Yao

AU - Yeh, Jong Shiuan

AU - Shih, Chun Ming

AU - Lin, Feng Yen

AU - Kao, Yung Ta

AU - Tsao, Nai Wen

AU - Hsiao, Wen Tien

AU - Chen, Jaw Wen

AU - Chang, Nen Chung

AU - Shyu, Kou-Gi

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The association between serum asymmetric dimethylarginine and coronary atherosclerotic plaque in an asymptomatic population

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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