The Ambivalent Role of lncRNA Xist in Carcinogenesis

Yung Kang Chen; Yun Yen

doi:10.1007/s12015-019-9871-z

The Ambivalent Role of lncRNA Xist in Carcinogenesis

Yung Kang Chen, Yun Yen

Research output: Contribution to journal › Article › peer-review

17 Citations (Scopus)

Abstract

Long non-coding RNA (lncRNA) Xist has emerged as a key modulator in dosage compensation by randomly inactivating one of the X chromosomes in mammals during embryonic development. Dysregulation of X chromosome inactivation (XCI) due to deletion of Xist has been proven to induce hematologic cancer in mice. However, this phenomenon is not consistent in humans as growing evidence suggests Xist can suppress or promote cancer growth in different organs of the human body. In this review, we discuss recent advances of XCI in human embryonic stem cells and provide an explanation for the seemingly contradictory roles of Xist in development of human cancer.

Original language	English
Pages (from-to)	314-323
Number of pages	10
Journal	Stem Cell Reviews and Reports
Volume	15
Issue number	2
DOIs	https://doi.org/10.1007/s12015-019-9871-z
Publication status	Published - Apr 15 2019

Keywords

Cancer stem cell
Competing endogenous RNA
Exosomes
Long non-coding RNA
MicroRNAs
X Chromosome inactivation
XACT non-coding RNA
XIST non-coding RNA

ASJC Scopus subject areas

Cell Biology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/s12015-019-9871-z

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abstract = "Long non-coding RNA (lncRNA) Xist has emerged as a key modulator in dosage compensation by randomly inactivating one of the X chromosomes in mammals during embryonic development. Dysregulation of X chromosome inactivation (XCI) due to deletion of Xist has been proven to induce hematologic cancer in mice. However, this phenomenon is not consistent in humans as growing evidence suggests Xist can suppress or promote cancer growth in different organs of the human body. In this review, we discuss recent advances of XCI in human embryonic stem cells and provide an explanation for the seemingly contradictory roles of Xist in development of human cancer.",

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KW - MicroRNAs

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KW - XIST non-coding RNA

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The Ambivalent Role of lncRNA Xist in Carcinogenesis

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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