TY - JOUR
T1 - The adipokines and inflammatory marker in young type 2 diabetics with metabolic syndrome
T2 - A pilot study
AU - Wen, Min Jie
AU - Hsieh, Chang Hsun
AU - Wu, Chung Ze
AU - Hsiao, Fone Ching
AU - Hsia, Te Lin
AU - Hung, Yi Jen
AU - Pei, Dee
N1 - Funding Information:
The present study was supported by the grant from both the Tri-Service General Hospital ( TSGH-C98-12-S02 ) and the cooperation research plan between National Defense Medical Center and Cardinal Tien Hospital ( NC97-01 ).
PY - 2013/5
Y1 - 2013/5
N2 - Objective: The purpose of the metabolic syndrome (MetS) concept was to early identify subjects having risk for developing cardiovascular diseases and diabetes, which of both are involved in low grade inflammation and obesity. We wish to explore the role of adipokines and inflammatory marker in young type 2 diabetics (YDM) with MetS. Methods: Forty-eight YDM patients were divided to 2 and 3 groups according to the presence of the MetS (MetS+ and MetS-), and the numbers of MetS component (MetS-2 to MetS-4 with 1-2, 3, and 4-5 components) respectively. Plasma adipokines (tumor necrosis factor-α; TNF-α and adiponectin) and C-reactive protein (CRP) were measured and compared among groups. Results: Blood pressure (BP), body mass index (BMI), and plasma triglyceride (TG) levels were higher in the group with MetS+ than that of MetS-. Except for diastolic BP, BMI, waist, and plasma TG levels, which were generally lower in the MetS-2 group, the rest demographic characteristics were not different among these three groups. Finally, the plasma adiponectin, CRP and TNF-αlevels were not different between both groups with or without MetS; and also among these three groups regardless the component numbers they had. Conclusion: YDM with MetS might have non-significant lower adiponectin and higher CRP levels compared to subjects without MetS. It needs prospective study with larger scale to explicit the role of cytokines and inflammatory markers in YDM with MetS.
AB - Objective: The purpose of the metabolic syndrome (MetS) concept was to early identify subjects having risk for developing cardiovascular diseases and diabetes, which of both are involved in low grade inflammation and obesity. We wish to explore the role of adipokines and inflammatory marker in young type 2 diabetics (YDM) with MetS. Methods: Forty-eight YDM patients were divided to 2 and 3 groups according to the presence of the MetS (MetS+ and MetS-), and the numbers of MetS component (MetS-2 to MetS-4 with 1-2, 3, and 4-5 components) respectively. Plasma adipokines (tumor necrosis factor-α; TNF-α and adiponectin) and C-reactive protein (CRP) were measured and compared among groups. Results: Blood pressure (BP), body mass index (BMI), and plasma triglyceride (TG) levels were higher in the group with MetS+ than that of MetS-. Except for diastolic BP, BMI, waist, and plasma TG levels, which were generally lower in the MetS-2 group, the rest demographic characteristics were not different among these three groups. Finally, the plasma adiponectin, CRP and TNF-αlevels were not different between both groups with or without MetS; and also among these three groups regardless the component numbers they had. Conclusion: YDM with MetS might have non-significant lower adiponectin and higher CRP levels compared to subjects without MetS. It needs prospective study with larger scale to explicit the role of cytokines and inflammatory markers in YDM with MetS.
KW - Adiponectin
KW - C-reactive protein
KW - Metabolic syndrome
KW - Tumor necrosis factor-α
KW - Young diabetes mellitus
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U2 - 10.1016/j.orcp.2011.12.002
DO - 10.1016/j.orcp.2011.12.002
M3 - Article
C2 - 23697589
AN - SCOPUS:84877579442
SN - 1871-403X
VL - 7
SP - e206-e210
JO - Obesity Research and Clinical Practice
JF - Obesity Research and Clinical Practice
IS - 3
ER -
