Testosterone inhibits prostacyclin production by rat aortic smooth muscle cells in culture

Junko Nakao; Wen Chang Chang; Sei Itsu Murota; Hajime Orimo

doi:10.1016/0021-9150(81)90070-8

Testosterone inhibits prostacyclin production by rat aortic smooth muscle cells in culture

Junko Nakao
, Wen Chang Chang
, Sei Itsu Murota
, Hajime Orimo

Research output: Contribution to journal › Article › peer-review

89 Citations (Scopus)

Abstract

The effects of testosterone on cell proliferation and prostacyclin production were investigated using rat aortic smooth muscle cells in culture. Testosterone at 10^-10 - 10^-6 M did not have any significant effect on cell proliferation, but it significantly inhibited prostacyclin production by the cells. Maximal inhibition of prostacyclin production (70%) was observed when cells were treated with a physiological concentration of 10^-8M testosterone for 5 consecutive days. These results suggest that testosterone may stimulate thrombus formation and accelerate atherosclerosis by suppressing prostacyclin production in arterial smooth muscle cells.

Original language	English
Pages (from-to)	203-209
Number of pages	7
Journal	Atherosclerosis
Volume	39
Issue number	2
DOIs	https://doi.org/10.1016/0021-9150(81)90070-8
Publication status	Published - May 1981
Externally published	Yes

Keywords

Atherosclerosis
Prostacyclin
Rat aortic smooth muscle cells
Testosterone

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine

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10.1016/0021-9150(81)90070-8

Cite this

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title = "Testosterone inhibits prostacyclin production by rat aortic smooth muscle cells in culture",

abstract = "The effects of testosterone on cell proliferation and prostacyclin production were investigated using rat aortic smooth muscle cells in culture. Testosterone at 10-10 - 10-6 M did not have any significant effect on cell proliferation, but it significantly inhibited prostacyclin production by the cells. Maximal inhibition of prostacyclin production (70\%) was observed when cells were treated with a physiological concentration of 10-8M testosterone for 5 consecutive days. These results suggest that testosterone may stimulate thrombus formation and accelerate atherosclerosis by suppressing prostacyclin production in arterial smooth muscle cells.",

keywords = "Atherosclerosis, Prostacyclin, Rat aortic smooth muscle cells, Testosterone",

author = "Junko Nakao and Chang, \{Wen Chang\} and Murota, \{Sei Itsu\} and Hajime Orimo",

year = "1981",

month = may,

doi = "10.1016/0021-9150(81)90070-8",

language = "English",

volume = "39",

pages = "203--209",

journal = "Atherosclerosis",

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AU - Nakao, Junko

AU - Chang, Wen Chang

AU - Murota, Sei Itsu

AU - Orimo, Hajime

PY - 1981/5

Y1 - 1981/5

N2 - The effects of testosterone on cell proliferation and prostacyclin production were investigated using rat aortic smooth muscle cells in culture. Testosterone at 10-10 - 10-6 M did not have any significant effect on cell proliferation, but it significantly inhibited prostacyclin production by the cells. Maximal inhibition of prostacyclin production (70%) was observed when cells were treated with a physiological concentration of 10-8M testosterone for 5 consecutive days. These results suggest that testosterone may stimulate thrombus formation and accelerate atherosclerosis by suppressing prostacyclin production in arterial smooth muscle cells.

AB - The effects of testosterone on cell proliferation and prostacyclin production were investigated using rat aortic smooth muscle cells in culture. Testosterone at 10-10 - 10-6 M did not have any significant effect on cell proliferation, but it significantly inhibited prostacyclin production by the cells. Maximal inhibition of prostacyclin production (70%) was observed when cells were treated with a physiological concentration of 10-8M testosterone for 5 consecutive days. These results suggest that testosterone may stimulate thrombus formation and accelerate atherosclerosis by suppressing prostacyclin production in arterial smooth muscle cells.

KW - Atherosclerosis

KW - Prostacyclin

KW - Rat aortic smooth muscle cells

KW - Testosterone

UR - https://www.scopus.com/pages/publications/0019454705

UR - https://www.scopus.com/pages/publications/0019454705#tab=citedBy

U2 - 10.1016/0021-9150(81)90070-8

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VL - 39

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EP - 209

JO - Atherosclerosis

JF - Atherosclerosis

IS - 2

ER -

Testosterone inhibits prostacyclin production by rat aortic smooth muscle cells in culture

Abstract

Keywords

ASJC Scopus subject areas

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