Abstract
The effects of testosterone on cell proliferation and prostacyclin production were investigated using rat aortic smooth muscle cells in culture. Testosterone at 10-10 - 10-6 M did not have any significant effect on cell proliferation, but it significantly inhibited prostacyclin production by the cells. Maximal inhibition of prostacyclin production (70%) was observed when cells were treated with a physiological concentration of 10-8M testosterone for 5 consecutive days. These results suggest that testosterone may stimulate thrombus formation and accelerate atherosclerosis by suppressing prostacyclin production in arterial smooth muscle cells.
Original language | English |
---|---|
Pages (from-to) | 203-209 |
Number of pages | 7 |
Journal | Atherosclerosis |
Volume | 39 |
Issue number | 2 |
DOIs | |
Publication status | Published - 1981 |
Externally published | Yes |
Keywords
- Atherosclerosis
- Prostacyclin
- Rat aortic smooth muscle cells
- Testosterone
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine