Terpenoids from the fermented broths of coprinellus radians

Ming Shian Lee; Che Jen Hsiao; Yu Ming Ju; Yueh Hsiung Kuo; Ruo Kai Lin; Tzong Huei Lee

doi:10.1177/1934578x1601100907

Terpenoids from the fermented broths of coprinellus radians

Ming Shian Lee, Che Jen Hsiao, Yu Ming Ju, Yueh Hsiung Kuo, Ruo Kai Lin, Tzong Huei Lee

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

One new sesquiterpenoid, namely coprinol (1), along with guanacastanes J (2), E (3) and N (4), were isolated from the ethyl acetate extracts of the fermented broths of the fungal strain Coprinellus radians #1168. Their structures were elucidated on the basis of spectroscopic data analysis. The growth inhibitory activities against A549 of 1-4 were evaluated, and only 4 exhibited moderate growth inhibitory activity with a GI₅₀ value of 18.2 μM compared with fluorouracil (GI50 = 3.6 μM). All the compounds were also subjected to antifungal assay against Candida albicans ATCC 18804, C. albicans SC-5314, Cryptococcus neoformans ATCC 13690 and Saccharomyces cerevisiae ATCC 2345; all showed mild antifungal activity with MIC values of 128.0 μg/mL for 1-3 and 64.0 μg/mL for 4 in comparison with amphotericin B (MIC = 0.25 μg/mL) and ketoconazole (MIC = 1.0 μg/mL).

Original language	English
Pages (from-to)	1229-1230
Number of pages	2
Journal	Natural Product Communications
Volume	11
Issue number	9
DOIs	https://doi.org/10.1177/1934578x1601100907
Publication status	Published - Sept 2016

Keywords

Antifungal assay
Coprinellus radians
Coprinol
Cytotoxicity
Guanacastane

ASJC Scopus subject areas

Pharmacology
Plant Science
Drug Discovery
Complementary and alternative medicine

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abstract = "One new sesquiterpenoid, namely coprinol (1), along with guanacastanes J (2), E (3) and N (4), were isolated from the ethyl acetate extracts of the fermented broths of the fungal strain Coprinellus radians #1168. Their structures were elucidated on the basis of spectroscopic data analysis. The growth inhibitory activities against A549 of 1-4 were evaluated, and only 4 exhibited moderate growth inhibitory activity with a GI50 value of 18.2 μM compared with fluorouracil (GI50 = 3.6 μM). All the compounds were also subjected to antifungal assay against Candida albicans ATCC 18804, C. albicans SC-5314, Cryptococcus neoformans ATCC 13690 and Saccharomyces cerevisiae ATCC 2345; all showed mild antifungal activity with MIC values of 128.0 μg/mL for 1-3 and 64.0 μg/mL for 4 in comparison with amphotericin B (MIC = 0.25 μg/mL) and ketoconazole (MIC = 1.0 μg/mL).",

keywords = "Antifungal assay, Coprinellus radians, Coprinol, Cytotoxicity, Guanacastane",

author = "Lee, {Ming Shian} and Hsiao, {Che Jen} and Ju, {Yu Ming} and Kuo, {Yueh Hsiung} and Lin, {Ruo Kai} and Lee, {Tzong Huei}",

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AU - Hsiao, Che Jen

AU - Ju, Yu Ming

AU - Kuo, Yueh Hsiung

AU - Lin, Ruo Kai

AU - Lee, Tzong Huei

PY - 2016/9

Y1 - 2016/9

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Terpenoids from the fermented broths of coprinellus radians

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Keywords

ASJC Scopus subject areas

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