Technical Error for Semi-quantitative Analysis of ^(99m)Tc-TRODAT-1 DAT SPECT- Case Report

Chih-Hao Chen; Ling-Shih  Chen; Jing-Long Hsu; Bang-Hung  Yang; Wen-Sheng  Huang; Chi-Jung  Tsai

doi:10.6663/TPART.202112_11(1).0005

Technical Error for Semi-quantitative Analysis of ^(99m)Tc-TRODAT-1 DAT SPECT- Case Report

Chih-Hao Chen, Ling-Shih Chen, Jing-Long Hsu, Bang-Hung Yang, Wen-Sheng Huang, Chi-Jung Tsai

Research output: Contribution to journal › Article › peer-review

Abstract

Parkinson's disease (PD) has been one of the most common diseases in the elderly since the late 20th century. In practice, diagnosis of PD is mainly relied on clinical criteria yet problems remain, especially in its early stage. ^(99m)Tc-TRODAT-1, a radioligand that selectively binds to dopamine transporter has been applied in clinical evaluation of PD using both visual and semi-quantitative analysis. The TRODAT Tool provides normalized quantitative data to assist disease diagnosis and its progression. However, an improper operation will result in an unexpected error diagnosis. Herein, we report a false negative diagnosis case due to a wrong direction adjustment.

Translated title of the contribution	關於多巴胺轉運體單光子斷層掃描半定量分析的技術錯誤－案例報告
Original language	English
Pages (from-to)	44-50
Number of pages	7
Journal	北市醫放雜誌
Volume	11
Issue number	1
DOIs	https://doi.org/10.6663/TPART.202112_11(1).0005
Publication status	Published - Dec 2021

Keywords

Parkinson's disease
^(99m)Tc-TRODAT-1 DAT SPECT
TRODAT Tool
Specific Uptake Ratio (SUR)
Asymmetric Index (ASI)
巴金森氏症
多巴胺轉運體
單光子斷層掃描
特異性攝取比值
不對稱性指標

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10.6663/TPART.202112_11(1).0005

http://dx.doi.org/10.6663/TPART.202112_11(1).0005

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title = "Technical Error for Semi-quantitative Analysis of ^(99m)Tc-TRODAT-1 DAT SPECT- Case Report",

abstract = "Parkinson's disease (PD) has been one of the most common diseases in the elderly since the late 20th century. In practice, diagnosis of PD is mainly relied on clinical criteria yet problems remain, especially in its early stage. ^(99m)Tc-TRODAT-1, a radioligand that selectively binds to dopamine transporter has been applied in clinical evaluation of PD using both visual and semi-quantitative analysis. The TRODAT Tool provides normalized quantitative data to assist disease diagnosis and its progression. However, an improper operation will result in an unexpected error diagnosis. Herein, we report a false negative diagnosis case due to a wrong direction adjustment.",

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author = "Chih-Hao Chen and Ling-Shih Chen and Jing-Long Hsu and Bang-Hung Yang and Wen-Sheng Huang and Chi-Jung Tsai",

year = "2021",

month = dec,

doi = "10.6663/TPART.202112_11(1).0005",

language = "English",

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T1 - Technical Error for Semi-quantitative Analysis of ^(99m)Tc-TRODAT-1 DAT SPECT- Case Report

AU - Chen, Chih-Hao

AU - Chen, Ling-Shih

AU - Hsu, Jing-Long

AU - Yang, Bang-Hung

AU - Huang, Wen-Sheng

AU - Tsai, Chi-Jung

PY - 2021/12

Y1 - 2021/12

N2 - Parkinson's disease (PD) has been one of the most common diseases in the elderly since the late 20th century. In practice, diagnosis of PD is mainly relied on clinical criteria yet problems remain, especially in its early stage. ^(99m)Tc-TRODAT-1, a radioligand that selectively binds to dopamine transporter has been applied in clinical evaluation of PD using both visual and semi-quantitative analysis. The TRODAT Tool provides normalized quantitative data to assist disease diagnosis and its progression. However, an improper operation will result in an unexpected error diagnosis. Herein, we report a false negative diagnosis case due to a wrong direction adjustment.

AB - Parkinson's disease (PD) has been one of the most common diseases in the elderly since the late 20th century. In practice, diagnosis of PD is mainly relied on clinical criteria yet problems remain, especially in its early stage. ^(99m)Tc-TRODAT-1, a radioligand that selectively binds to dopamine transporter has been applied in clinical evaluation of PD using both visual and semi-quantitative analysis. The TRODAT Tool provides normalized quantitative data to assist disease diagnosis and its progression. However, an improper operation will result in an unexpected error diagnosis. Herein, we report a false negative diagnosis case due to a wrong direction adjustment.

KW - Parkinson's disease

KW - ^(99m)Tc-TRODAT-1 DAT SPECT

KW - TRODAT Tool

KW - Specific Uptake Ratio (SUR)

KW - Asymmetric Index (ASI)

KW - 巴金森氏症

KW - 多巴胺轉運體

KW - 單光子斷層掃描

KW - 特異性攝取比值

KW - 不對稱性指標

U2 - 10.6663/TPART.202112_11(1).0005

DO - 10.6663/TPART.202112_11(1).0005

M3 - Article

SN - 2308-300X

VL - 11

SP - 44

EP - 50

JO - 北市醫放雜誌

JF - 北市醫放雜誌

IS - 1

ER -

Technical Error for Semi-quantitative Analysis of ^(99m)Tc-TRODAT-1 DAT SPECT- Case Report

Abstract

Keywords

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