Technetium-99m-HMPAO brain SPECT in neonates with hypoglycemic encephalopathy

Nan Tsing Chiu, Chao Ching Huang, Ying Chao Chang, Chyi Her Lin, Wei Jen Yao, Chin Yin Yu

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16 Citations (Scopus)


Regional brain injury in three neonates with hypoglycemic encephalopathy are presented using serial 99mTc-hexamethyl propyleneamine oxime (HMPAO) SPECT and, for comparison, MRI. During the acute stage, both 99mTc-HMPAO SPECT and MRI reveal abnormalities in the posterior cerebrum. Technetium- 99m-HMPAO SPECT reveals further areas of insult, for example the frontal lobes. The degree of hypoperfusion correlates with the clinical severity of hypoglycemia during the neonatal period and subsequent neurological sequelae. Follow-up with HMPAO SPECT several months after insult demonstrates persistent hypoperfusion in some areas, mainly in the occipital and posterior parietal regions. MRI can depict morphological changes with superior resolution. Because morphological change generally follows slowly after functional change, MRI is less sensitive than HMPAO SPECT in detecting and predicting the extent of hypoglycemic cerebral injury during the acute phase. HMPAO SPECT during the acute stage is a valuable tool for evaluating the extent and severity of brain injury in neonates with hypoglycemic encephalopathy.

Original languageEnglish
Pages (from-to)1711-1713
Number of pages3
JournalJournal of Nuclear Medicine
Issue number10
Publication statusPublished - Oct 1998
Externally publishedYes


  • Hypoglycemia
  • Neonate
  • Seizure

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


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