TDP-43, a neuro-pathosignature factor, is essential for early mouse embryogenesis

Lien Szu Wu, Wei Cheng, Shin Chen Hou, Yu Ting Yan, Si Tse Jiang, C. K.James Shen

Research output: Contribution to journalArticlepeer-review

223 Citations (Scopus)


TDP-43 is a highly conserved and ubiquitously expressed nuclear protein. It has been implicated in the regulation of transcription, alternative splicing, translation, and neuronal plasticity. TDP-43 has also been shown to be a disease signature protein associated with several neurodegenerative diseases including amyotrophic lateral sclerosis. However, the correlation of the physiological functions of TDP-43 with these diseases remains unknown. We have used the gene targeting approach to disrupt the expression of TDP-43 in mouse. Loss of the TDP-43 expression results in peri-implantation lethality of mice between embryonic days (E) 3.5 and 6.5. Blastocysts of the homozygous Tardbp null mutants are morphologically normal, but exhibit defective outgrowth of the inner cell mass in vitro. Our data demonstrate the essential function of TDP-43 in peri-implantation stage during the embryo development, likely because of its involvement in multiple biological processes in a variety of cell types.

Original languageEnglish
Pages (from-to)56-62
Number of pages7
Issue number1
Publication statusPublished - Jan 1 2010
Externally publishedYes


  • Development
  • Gene knockout
  • Inner cell mass
  • Lethality
  • TDP-43

ASJC Scopus subject areas

  • Genetics
  • Endocrinology
  • Cell Biology


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