Targeting therapeutic agent against C3b/C4b, SB002, on the inflammation-induced bone loss in experimental periodontitis

Ren Yeong Huang, Fang Yi Tseng, Jhong Jhe You, Thomas E. Van Dyke, Chia Dan Cheng, Cheng En Sung, Pei Wei Weng, Yi Shing Shieh, Wan Chien Cheng

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)

Abstract

Aims: To use experimental periodontitis models in rats to investigate the correlation between local expression of the complement components C3b and C4b in periodontal tissues and disease severity, and to assess the therapeutic effects of targeting C3b/C4b on inflammatory bone loss. Materials and Methods: The gingival expression of C3, C3b, and C4b in animal experimental periodontitis models were analysed immunohistochemically. The therapeutic effects of the C3b/C4b inhibitor (SB002) on ligation-induced experimental periodontitis was examined using biochemical, histological, and immunohistochemical analyses. Results: The gingival expression levels of C3, C3b, and C4b were positively correlated with the severity of periodontitis. Moreover, both single and multiple injections of the C3b/C4b inhibitor had preventive and therapeutic effects on alveolar bone loss in ligation-induced experimental periodontitis with no associated adverse consequences. Conclusions: The association between C3b/C4b and periodontitis may provide a basis for the development of novel therapeutic strategies for periodontitis and other inflammatory diseases.

Original languageEnglish
Pages (from-to)657-670
Number of pages14
JournalJournal of Clinical Periodontology
Volume50
Issue number5
DOIs
Publication statusAccepted/In press - 2023

Keywords

  • bone loss
  • C3b
  • C4b
  • complement
  • experimental periodontitis
  • therapeutic use

ASJC Scopus subject areas

  • Periodontics

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