Abstract
| Original language | English |
|---|---|
| Pages (from-to) | 4319-4331 |
| Number of pages | 13 |
| Journal | Clinical Cancer Research |
| Volume | 24 |
| Issue number | 17 |
| DOIs | |
| Publication status | Published - 2018 |
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In: Clinical Cancer Research, Vol. 24, No. 17, 2018, p. 4319-4331.
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}
TY - JOUR
T1 - Targeting galectin-1 impairs castration-resistant prostate cancer progression and invasion
AU - Shih, T.-C.
AU - Liu, R.
AU - Wu, C.-T.
AU - Li, X.
AU - Xiao, W.
AU - Deng, X.
AU - Kiss, S.
AU - Wang, T.
AU - Chen, X.-J.
AU - Carney, R.
AU - Kung, H.-J.
AU - Duan, Y.
AU - Ghosh, P.M.
AU - Lam, K.S.
N1 - Export Date: 30 October 2018 CODEN: CCREF 通訊地址: Lam, K.S.; UC Davis NCI-designated Comprehensive Cancer Center, University of California, DavisUnited States; 電子郵件: [email protected] 參考文獻: Siegel, R.L., Miller, K.D., Jemal, A., Cancer statistics, 2017 (2017) CA Cancer J Clin, 67, pp. 7-30; Huggins, C., Hodges, C.V., The effect of castration, of estrogen and of androgen injection on serum phosphatases in metastatic carcinoma of the prostate (1941) Cancer Res, 1, pp. 293-297; Cookson, M.S., Roth, B.J., Dahm, P., Engstrom, C., Freedland, S.J., Hussain, M., Castration-resistant prostate cancer: AUA guideline (2013) J Urol, 190, pp. 429-438; Zhang, P., Zhang, P., Shi, B., Zhou, M., Jiang, H., Zhang, H., Galectin-1 overexpression promotes progression and chemoresistance to cisplatin in epithelial ovarian cancer (2014) Cell Death Dis, 5, p. e991; Carlini, M.J., Roitman, P., Nunez, M., Pallotta, M.G., Boggio, G., Smith, D., Clinical relevance of galectin-1 expression in non-small cell lung cancer patients (2014) Lung Cancer, 84, pp. 73-78; Jung, E.J., Moon, H.G., Cho, B.I., Jeong, C.Y., Joo, Y.T., Lee, Y.J., Galectin-1 expression in cancer-associated stromal cells correlates tumor invasiveness and tumor progression in breast cancer (2007) Int J Cancer, 120, pp. 2331-2338; White, N.M., Masui, O., Newsted, D., Scorilas, A., Romaschin, A.D., Bjarnason, G.A., Galectin-1 has potential prognostic significance and is implicated in clear cell renal cell carcinoma progression through the HIF/mTOR signaling axis (2014) Br J Cancer, 110, pp. 1250-1259; Martinez-Bosch, N., Fernandez-Barrena, M.G., Moreno, M., Ortiz-Zapater, E., Munne-Collado, J., Iglesias, M., Galectin-1 drives pancreatic carcinogenesis through stroma remodeling and hedgehog signaling activation (2014) Cancer Res, 74, pp. 3512-3524; Liu, F.T., Rabinovich, G.A., Galectins as modulators of tumour progression (2005) Nat Rev Cancer, 5, pp. 29-41; Perillo, N.L., Pace, K.E., Seilhamer, J.J., Baum, L.G., Apoptosis of T cells mediated by galectin-1 (1995) Nature, 378, pp. 736-739; Rubinstein, N., Alvarez, M., Zwirner, N.W., Toscano, M.A., Ilarregui, J.M., Bravo, A., Targeted inhibition of galectin-1 gene expression in tumor cells results in heightened T cell-mediated rejection (2004) Cancer Cell, 5, pp. 241-251; Fischer, C., Sanchez-Ruderisch, H., Welzel, M., Wiedenmann, B., Sakai, T., Andre, S., Galectin-1 interacts with the a5b1 fibronectin receptor to restrict carcinoma cell growth via induction of p21 and p27 (2005) J Biol Chem, 280, pp. 37266-37277; Wells, V., Davies, D., Mallucci, L., Cell cycle arrest and induction of apoptosis by beta galactoside binding protein (beta GBP) in human mammary cancer cells. A potential new approach to cancer control (1999) Eur J Cancer, 35, pp. 978-983; Stanley, P., Galectin-1 pulls the strings on VEGFR2 (2014) Cell, 156, pp. 625-626; Hsu, Y.L., Wu, C.Y., Hung, J.Y., Lin, Y.S., Huang, M.S., Kuo, P.L., Galectin-1 promotes lung cancer tumor metastasis by potentiating integrin alpha6beta4 and Notch1/Jagged2 signaling pathway (2013) Carcinogenesis, 34, pp. 1370-1381; Qian, D., Lu, Z., Xu, Q., Wu, P., Tian, L., Zhao, L., Galectin-1-driven upregulation of SDF-1 in pancreatic stellate cells promotes pancreatic cancer metastasis (2017) Cancer Lett, 397, pp. 43-51; Wu, M.-H., Hong, T.-M., Cheng, H.-W., Pan, S.-H., Liang, Y.-R., Hong, H.-C., Galectin-1-mediated tumor invasion and metastasis, up-regulated matrix metalloproteinase expression, and reorganized actin cytoskeletons (2009) Mol Cancer Res, 7, pp. 311-318; van den Brûle, F.A., Waltregny, D., Castronovo, V., Increased expression of galectin-1 in carcinoma-associated stroma predicts poor outcome in prostate carcinoma patients (2001) J Pathol, 193, pp. 80-87; Laderach, D.J., Gentilini, L.D., Giribaldi, L., Delgado, V.C., Nugnes, L., Croci, D.O., A unique galectin signature in human prostate cancer progression suggests galectin-1 as a key target for treatment of advanced disease (2013) Cancer Res, 73, pp. 86-96; Shih, T.-C., Liu, R., Fung, G., Bhardwaj, G., Ghosh, P.M., Lam, K.S., Anovelgalectin-1 inhibitor discovered through one-bead-two-compounds library potentiates the anti-tumor effects of paclitaxel in vivo (2017) Mol Cancer Ther, 6, pp. 1212-1223; Blanchard, H., Bum-Erdene, K., Bohari, M.H., Yu, X., Galectin-1 inhibitors and their potential therapeutic applications: A patent review (2016) Expert Opin Ther Pat, 26, pp. 537-554; Epstein, J.I., Allsbrook, W.C., Jr, Amin, M.B., Egevad, L.L., The 2005 International Society of Urological Pathology (ISUP) consensus conference on Gleason grading of prostatic carcinoma (2005) Am J Surg Pathol, 29, pp. 1228-1242; Hsieh, S.Y., Shih, T.C., Yeh, C.Y., Lin, C.J., Chou, Y.Y., Lee, Y.S., Comparative proteomic studies on the pathogenesis of human ulcerative colitis (2006) Prote-Omics, 6, pp. 5322-5331; Laderach, D.J., Gentilini, L.D., Giribaldi, L., Delgado, V.C., Nugnes, L., Croci, D.O., A unique galectin signature in human prostate cancer progression suggests galectin-1 as a key target for treatment of advanced disease (2013) Cancer Res, 73, pp. 86-96; Shih, T.-C., Liu, R., Fung, G., Bhardwaj, G., Ghosh, P.M., Lam, K.S., A novel galectin-1 inhibitor discovered through one-bead two-compound library potentiates the antitumor effects of paclitaxel in vivo (2017) Mol Cancer Ther, 16, pp. 1212-1223; Moiseeva, E.P., Williams, B., Samani, N.J., Galectin 1 inhibits incorporation of vitronectin and chondroitin sulfate B into the extracellular matrix of human vascular smooth muscle cells (2003) Biochim Biophys Acta, 1619, pp. 125-132; Kinkade, C.W., Castillo-Martin, M., Puzio-Kuter, A., Yan, J., Foster, T.H., Gao, H., Targeting AKT/mTOR and ERK MAPK signaling inhibits hormone-refractory prostate cancer in a preclinical mouse model (2008) J Clin Invest, 118, pp. 3051-3064; Sarker, D., Reid, A.H.M., Yap, T.A., De Bono, J.S., Targeting the PI3K/AKT pathway for the treatment of prostate cancer (2009) Clin Cancer Res, 15, pp. 4799-4805; Malik, S.N., Brattain, M., Ghosh, P.M., Troyer, D.A., Prihoda, T., Bedolla, R., Immunohistochemical demonstration of phospho-Akt in high Gleason grade prostate cancer (2002) Clin Cancer Res, 8, pp. 1168-1171; Paz, A., Haklai, R., Elad-Sfadia, G., Ballan, E., Kloog, Y., Galectin-1 binds oncogenic H-Ras to mediate Ras membrane anchorage and cell transformation (2001) Oncogene, 20, pp. 7486-7493; Deep, G., Agarwal, R., New combination therapies with cell cycle agents (2008) Curr Opin Investig Drugs, 9, pp. 591-604; Zalatnai, A., Potential role of cell cycle synchronizing agents in combination treatment modalities of malignant tumors (2005) Vivo, 19, pp. 85-91; Johnson, T.R., Khandrika, L., Kumar, B., Venezia, S., Koul, S., Chandhoke, R., Focal adhesion kinase controls aggressive phenotype of androgen-independent prostate cancer (2008) Mol Cancer Res, 6, pp. 1639-1648; Das, R., Gregory, P.A., Fernandes, R.C., Denis, I., Wang, Q., Townley, S.L., MicroRNA-194 promotes prostate cancer metastasis by inhibiting SOCS2 (2016) Cancer Res, 77, pp. 1021-1034; Stangelberger, A., Schally, A.V., Varga, J.L., Zarandi, M., Szepeshazi, K., Armatis, P., Inhibitory effect of antagonists of bombesin and growth hormone-releasing hormone on orthotopic and intraosseous growth and invasiveness of PC-3 human prostate cancer in nude mice (2005) Clin Cancer Res, 11, pp. 49-57; Tannock, I.F., De Wit, R., Berry, W.R., Horti, J., Pluzanska, A., Chi, K.N., Docetaxel plus prednisone or mitoxantrone plus prednisone for advanced prostate cancer (2004) N Engl J Med, 351, pp. 1502-1512; De Bono, J.S., Oudard, S., Ozguroglu, M., Hansen, S., Machiels, J.P., Kocak, I., Prednisone plus cabazitaxel or mitoxantrone for metastatic castration-resistant prostate cancer progressing after docetaxel treatment: A rando-mised open-label trial (2010) Lancet, 376, pp. 1147-1154; De Bono, J.S., Logothetis, C.J., Molina, A., Fizazi, K., North, S., Chu, L., Abiraterone and increased survival in metastatic prostate cancer (2011) N Engl J Med, 364, pp. 1995-2005; Scher, H.I., Fizazi, K., Saad, F., Taplin, M.E., Sternberg, C.N., Miller, K., Increased survival with enzalutamide in prostate cancer after chemotherapy (2012) N Engl J Med, 367, pp. 1187-1197; Claessens, F., Helsen, C., Prekovic, S., Van den Broeck, T., Spans, L., Van Poppel, H., Emerging mechanisms of enzalutamide resistance in prostate cancer (2014) Nat Rev Urol, 11, p. 712; Attard, G., Antonarakis, E.S., AR aberrations and resistance to abiraterone or enzalutamide (2016) Nat Rev Urol, 13, p. 697; Karantanos, T., Corn, P.G., Thompson, T.C., Prostate cancer progression after androgen deprivation therapy: Mechanisms of castrate resistance and novel therapeutic approaches (2013) Oncogene, 32, p. 5501; Mostaghel, E.A., Marck, B.T., Plymate, S., Vessella, R., Balk, S., Matsumoto, A.M., Resistance to CYP17A1 inhibition with abiraterone in castration resistant prostate cancer: Induction of steroidogenesis and androgen receptor splice variants (2011) Clin Cancer Res, 17, pp. 5913-5925; Li, Y., Chan, S.C., Brand, L.J., Hwang, T.H., Silverstein, K.A.T., Dehm, S.M., Androgen receptor splice variants mediate enzalutamide resistance in castration-resistant prostate cancer cell lines (2013) Cancer Res, 73, pp. 483-489; Zhang, P., Zhang, P., Shi, B., Zhou, M., Jiang, H., Zhang, H., Galectin-1 overexpression promotes progression and chemoresistance to cisplatin in epithelial ovarian cancer (2014) Cell Death Dis, 5, p. e991; Astorgues-Xerri, L., Riveiro, M.E., Tijeras-Raballand, A., Serova, M., Rabinovich, G.A., Bieche, I., OTX008, a selective small-molecule inhibitor of galectin-1, downregulates cancer cell proliferation, invasion and tumour angiogenesis (2014) Eur J Cancer, 50, pp. 2463-2477; Dings, R.P.M., Miller, M.C., Nesmelova, I., Astorgues-Xerri, L., Kumar, N., Serova, M., Antitumor agent calixarene 0118 targets human galectin-1 as an allosteric inhibitor of carbohydrate binding (2012) J Med Chem, 55, pp. 5121-5129; Chang, L., Graham, P.H., Ni, J., Hao, J., Bucci, J., Cozzi, P.J., Targeting PI3K/ Akt/mTOR signaling pathway in the treatment of prostate cancer radio-resistance (2015) Crit Rev Oncol Hematol, 96, pp. 507-517; Knudsen, K.E., Arden, K.C., Cavenee, W.K., Multiple G1 regulatory elements control the androgen-dependent proliferation of prostatic carcinoma cells (1998) J Biol Chem, 273, pp. 20213-20222; Agus, D.B., Cordon-Cardo, C., Fox, W., Drobnjak, M., Koff, A., Golde, D.W., Prostate cancer cell cycle regulators: Response to androgen withdrawal and development of androgen independence (1999) J Nat Cancer Inst, 91, pp. 1869-1876; Ruoslahti, E., Integrins (1991) J Clin Invest, 87, pp. 1-5; Hynes, R.O., Integrins: Versatility, modulation, and signaling in cell adhesion (1992) Cell, 69, pp. 11-25; Mitra, S.K., Schlaepfer, D.D., Integrin-regulated FAK–Src signaling in normal and cancer cells (2006) Curr Opin Cell Biol, 18, pp. 516-523; Cress, A.E., Rabinovitz, I., Zhu, W., Nagle, R.B., The a6b1 and a6b4 integrins in human prostate cancer progression (1995) Cancer Metastasis Rev, 14, pp. 219-228; Yoshioka, T., Otero, J., Chen, Y., Kim, Y.-M., Koutcher, J.A., Satagopan, J., B4 Integrin signaling induces expansion of prostate tumor progenitors (2013) J Clin Invest, 123, pp. 682-699; Thijssen, V.L., Postel, R., Brandwijk, R.J., Dings, R.P., Nesmelova, I., Satijn, S., Galectin-1 is essential in tumor angiogenesis and is a target for antiangio-genesis therapy (2006) Proc Natl Acad Sci U S A, 103, pp. 15975-15980; Perillo, N.L., Pace, K.E., Seilhamer, J.J., Baum, L.G., Apoptosis of T cells mediated by galectin-1 (1995) Nature, 378, pp. 736-739; Gevensleben, H., Dietrich, D., Golletz, C., Steiner, S., Jung, M., Thiesler, T., The immune checkpoint regulator PD-L1 is highly expressed in aggressive primary prostate cancer (2016) Clin Cancer Res, 22, pp. 1969-1977; St-Pierre, C., Ouellet, M., Giguere, D., Ohtake, R., Roy, R., Sato, S., Galectin-1specific inhibitors as a new class of compounds to treat HIV-1 infection (2012) Antimicrob Agents Chemother, 56, pp. 154-162; Sato, S., Ouellet, M., St-Pierre, C., Tremblay, M.J., Glycans, galectins, and HIV-1 infection (2012) Ann N Y Acad Sci, 1253, pp. 133-148; Salatino, M., Croci, D.O., Bianco, G.A., Ilarregui, J.M., Toscano, M.A., Rabinovich, G.A., Galectin-1 as a potential therapeutic target in autoimmune disorders and cancer (2008) Expert Opin Biol Ther, 8, pp. 45-57; Mukherjee, R., Kim, S.W., Park, T., Choi, M.S., Yun, J.W., Targeted inhibition of galectin 1 by thiodigalactoside dramatically reduces body weight gain in diet-induced obese rats (2015) Int J Obes, 39, pp. 1349-1358
PY - 2018
Y1 - 2018
N2 - Purpose: The majority of patients with prostate cancer who are treated with androgen-deprivation therapy (ADT) will eventually develop fatal metastatic castration-resistant prostate cancer (mCRPC). Currently, there are no effective durable therapies for patients with mCRPC. High expression of galectin-1 (Gal-1) is associated with prostate cancer progression and poor clinical outcome. The role of Gal-1 in tumor progression is largely unknown. Here, we characterized Gal-1 functions and evaluated the therapeutic effects of a newly developed Gal-1 inhibitor, LLS30, in mCRPC. Experimental Design: Cell viability, colony formation, migration, and invasion assays were performed to examine the effects of inhibition of Gal-1 in CRPC cells. We used two human CRPC xenograft models to assess growth-inhibitory effects of LLS30. Genome-wide gene expression analysis was conducted to elucidate the effects of LLS30 on metastatic PC3 cells. Results: Gal-1 was highly expressed in CRPC cells, but not in androgen-sensitive cells. Gal-1 knockdown significantly inhibited CRPC cells' growth, anchorage-independent growth, migration, and invasion through the suppression of androgen receptor (AR) and Akt signaling. LLS30 targets Gal-1 as an allosteric inhibitor and decreases Gal-1–binding affinity to its binding partners. LLS30 showed in vivo efficacy in both AR-positive and AR-negative xenograft models. LLS30 not only can potentiate the antitumor effect of docetaxel to cause complete regression of tumors, but can also effectively inhibit the invasion and metastasis of prostate cancer cells in vivo. Conclusions: Our study provides evidence that Gal-1 is an important target for mCRPC therapy, and LLS30 is a promising small-molecule compound that can potentially overcome mCRPC. © 2018 American Association for Cancer Research.
AB - Purpose: The majority of patients with prostate cancer who are treated with androgen-deprivation therapy (ADT) will eventually develop fatal metastatic castration-resistant prostate cancer (mCRPC). Currently, there are no effective durable therapies for patients with mCRPC. High expression of galectin-1 (Gal-1) is associated with prostate cancer progression and poor clinical outcome. The role of Gal-1 in tumor progression is largely unknown. Here, we characterized Gal-1 functions and evaluated the therapeutic effects of a newly developed Gal-1 inhibitor, LLS30, in mCRPC. Experimental Design: Cell viability, colony formation, migration, and invasion assays were performed to examine the effects of inhibition of Gal-1 in CRPC cells. We used two human CRPC xenograft models to assess growth-inhibitory effects of LLS30. Genome-wide gene expression analysis was conducted to elucidate the effects of LLS30 on metastatic PC3 cells. Results: Gal-1 was highly expressed in CRPC cells, but not in androgen-sensitive cells. Gal-1 knockdown significantly inhibited CRPC cells' growth, anchorage-independent growth, migration, and invasion through the suppression of androgen receptor (AR) and Akt signaling. LLS30 targets Gal-1 as an allosteric inhibitor and decreases Gal-1–binding affinity to its binding partners. LLS30 showed in vivo efficacy in both AR-positive and AR-negative xenograft models. LLS30 not only can potentiate the antitumor effect of docetaxel to cause complete regression of tumors, but can also effectively inhibit the invasion and metastasis of prostate cancer cells in vivo. Conclusions: Our study provides evidence that Gal-1 is an important target for mCRPC therapy, and LLS30 is a promising small-molecule compound that can potentially overcome mCRPC. © 2018 American Association for Cancer Research.
U2 - 10.1158/1078-0432.CCR-18-0157
DO - 10.1158/1078-0432.CCR-18-0157
M3 - Article
SN - 1078-0432
VL - 24
SP - 4319
EP - 4331
JO - Clinical Cancer Research
JF - Clinical Cancer Research
IS - 17
ER -