Targeted delivery of paclitaxel and doxorubicin to cancer xenografts via the nanoparticle of nano-diamino-tetrac

Thangirala Sudha; Dhruba J. Bharali; Murat Yalcin; Noureldien H.E. Darwish; Melis Debreli Coskun; Kelly A. Keating; Hung Yun Lin; Paul J. Davis; Shaker A. Mousa

doi:10.2147/IJN.S123742

Targeted delivery of paclitaxel and doxorubicin to cancer xenografts via the nanoparticle of nano-diamino-tetrac

Thangirala Sudha, Dhruba J. Bharali, Murat Yalcin, Noureldien H.E. Darwish, Melis Debreli Coskun, Kelly A. Keating, Hung Yun Lin, Paul J. Davis, Shaker A. Mousa

Research output: Contribution to journal › Article › peer-review

37 Citations (Scopus)

Abstract

The tetraiodothyroacetic acid (tetrac) component of nano-diamino-tetrac (NDAT) is chemically bonded via a linker to a poly(lactic-co-glycolic acid) nanoparticle that can encapsulate anticancer drugs. Tetrac targets the plasma membrane of cancer cells at a receptor on the extracellular domain of integrin αvβ3. In this study, we evaluate the efficiency of NDAT delivery of paclitaxel and doxorubicin to, respectively, pancreatic and breast cancer orthotopic nude mouse xenografts. Intra-tumoral drug concentrations were 5-fold (paclitaxel; P<0.001) and 2.3-fold (doxorubicin; P<0.01) higher than with conventional systemic drug administration. Tumor volume reductions reflected enhanced xenograft drug uptake. Cell viability was estimated by bioluminescent signaling in pancreatic tumors and confirmed an increased paclitaxel effect with drug delivery by NDAT. NDAT delivery of chemotherapy increases drug delivery to cancers and increases drug efficacy.

Original language	English
Pages (from-to)	1305-1315
Number of pages	11
Journal	International Journal of Nanomedicine
Volume	12
DOIs	https://doi.org/10.2147/IJN.S123742
Publication status	Published - Feb 15 2017

Keywords

Doxorubicin
Integrin
NDAT
Nanoparticle
Nanotetrac
Paclitaxel
Tetraiodothyroacetic acid
Xenografts

ASJC Scopus subject areas

Biophysics
Bioengineering
Biomaterials
Pharmaceutical Science
Drug Discovery
Organic Chemistry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.2147/IJN.S123742

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title = "Targeted delivery of paclitaxel and doxorubicin to cancer xenografts via the nanoparticle of nano-diamino-tetrac",

abstract = "The tetraiodothyroacetic acid (tetrac) component of nano-diamino-tetrac (NDAT) is chemically bonded via a linker to a poly(lactic-co-glycolic acid) nanoparticle that can encapsulate anticancer drugs. Tetrac targets the plasma membrane of cancer cells at a receptor on the extracellular domain of integrin αvβ3. In this study, we evaluate the efficiency of NDAT delivery of paclitaxel and doxorubicin to, respectively, pancreatic and breast cancer orthotopic nude mouse xenografts. Intra-tumoral drug concentrations were 5-fold (paclitaxel; P<0.001) and 2.3-fold (doxorubicin; P<0.01) higher than with conventional systemic drug administration. Tumor volume reductions reflected enhanced xenograft drug uptake. Cell viability was estimated by bioluminescent signaling in pancreatic tumors and confirmed an increased paclitaxel effect with drug delivery by NDAT. NDAT delivery of chemotherapy increases drug delivery to cancers and increases drug efficacy.",

keywords = "Doxorubicin, Integrin, NDAT, Nanoparticle, Nanotetrac, Paclitaxel, Tetraiodothyroacetic acid, Xenografts",

author = "Thangirala Sudha and Bharali, {Dhruba J.} and Murat Yalcin and Darwish, {Noureldien H.E.} and Coskun, {Melis Debreli} and Keating, {Kelly A.} and Lin, {Hung Yun} and Davis, {Paul J.} and Mousa, {Shaker A.}",

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doi = "10.2147/IJN.S123742",

language = "English",

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AU - Sudha, Thangirala

AU - Bharali, Dhruba J.

AU - Yalcin, Murat

AU - Darwish, Noureldien H.E.

AU - Coskun, Melis Debreli

AU - Keating, Kelly A.

AU - Lin, Hung Yun

AU - Davis, Paul J.

AU - Mousa, Shaker A.

PY - 2017/2/15

Y1 - 2017/2/15

N2 - The tetraiodothyroacetic acid (tetrac) component of nano-diamino-tetrac (NDAT) is chemically bonded via a linker to a poly(lactic-co-glycolic acid) nanoparticle that can encapsulate anticancer drugs. Tetrac targets the plasma membrane of cancer cells at a receptor on the extracellular domain of integrin αvβ3. In this study, we evaluate the efficiency of NDAT delivery of paclitaxel and doxorubicin to, respectively, pancreatic and breast cancer orthotopic nude mouse xenografts. Intra-tumoral drug concentrations were 5-fold (paclitaxel; P<0.001) and 2.3-fold (doxorubicin; P<0.01) higher than with conventional systemic drug administration. Tumor volume reductions reflected enhanced xenograft drug uptake. Cell viability was estimated by bioluminescent signaling in pancreatic tumors and confirmed an increased paclitaxel effect with drug delivery by NDAT. NDAT delivery of chemotherapy increases drug delivery to cancers and increases drug efficacy.

AB - The tetraiodothyroacetic acid (tetrac) component of nano-diamino-tetrac (NDAT) is chemically bonded via a linker to a poly(lactic-co-glycolic acid) nanoparticle that can encapsulate anticancer drugs. Tetrac targets the plasma membrane of cancer cells at a receptor on the extracellular domain of integrin αvβ3. In this study, we evaluate the efficiency of NDAT delivery of paclitaxel and doxorubicin to, respectively, pancreatic and breast cancer orthotopic nude mouse xenografts. Intra-tumoral drug concentrations were 5-fold (paclitaxel; P<0.001) and 2.3-fold (doxorubicin; P<0.01) higher than with conventional systemic drug administration. Tumor volume reductions reflected enhanced xenograft drug uptake. Cell viability was estimated by bioluminescent signaling in pancreatic tumors and confirmed an increased paclitaxel effect with drug delivery by NDAT. NDAT delivery of chemotherapy increases drug delivery to cancers and increases drug efficacy.

KW - Doxorubicin

KW - Integrin

KW - NDAT

KW - Nanoparticle

KW - Nanotetrac

KW - Paclitaxel

KW - Tetraiodothyroacetic acid

KW - Xenografts

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Targeted delivery of paclitaxel and doxorubicin to cancer xenografts via the nanoparticle of nano-diamino-tetrac

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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