Abstract
Ultraviolet B (UVB) radiation may cause the inflammation of retinal pigment epithelium (RPE) cells and play a role in development of age-related macular degeneration (AMD). The activation of the complement factor B (CFB) gene has been shown to be involved in formation of AMD. Here our results revealed that UVB induces IL-6/STAT3 signaling activation and the UVB-induced STAT3 is able to regulate the CFB expression in ARPE-19 cells. Tannic acid (TA) is a kind of water-soluble polyphenol and may have anti-inflammation effects. We also found that TA attenuates the UVB-induced IL-6 protein production, the STAT3 phosphorylation and the CFB expression. Taken together, these findings suggest UVB-induced inflammation of RPE can be mediated through the IL-6/STAT3/CFB pathway, and TA has a protected effect via the inhibition to the inflammatory response.
Original language | English |
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Pages (from-to) | 79-84 |
Number of pages | 6 |
Journal | Cellular Immunology |
Volume | 273 |
Issue number | 1 |
DOIs | |
Publication status | Published - 2012 |
Keywords
- Complement factor B
- Inflammation
- Interleukin-6
- RPE
- Ultraviolet
ASJC Scopus subject areas
- Immunology