TACCO, a Database Connecting Transcriptome Alterations, Pathway Alterations and Clinical Outcomes in Cancers

Po Hao Chou; Wei Chao Liao; Kuo Wang Tsai; Ku Chung Chen; Jau Song Yu; Ting Wen Chen

doi:10.1038/s41598-019-40629-z

TACCO, a Database Connecting Transcriptome Alterations, Pathway Alterations and Clinical Outcomes in Cancers

Po Hao Chou, Wei Chao Liao, Kuo Wang Tsai, Ku Chung Chen, Jau Song Yu, Ting Wen Chen

Department of Biochemistry and Molecular Cell Biology

Research output: Contribution to journal › Article › peer-review

15 Citations (Scopus)

Abstract

Because of innumerable cancer sequencing projects, abundant transcriptome expression profiles together with survival data are available from the same patients. Although some expression signatures for prognosis or pathologic staging have been identified from these data, systematically discovering such kind of expression signatures remains a challenge. To address this, we developed TACCO (Transcriptome Alterations in CanCer Omnibus), a database for identifying differentially expressed genes and altered pathways in cancer. TACCO also reveals miRNA cooperative regulations and supports construction of models for prognosis. The resulting signatures have great potential for patient stratification and treatment decision-making in future clinical applications. TACCO is freely available at http://tacco.life.nctu.edu.tw/.

Original language	English
Article number	3877
Journal	Scientific Reports
Volume	9
Issue number	1
DOIs	https://doi.org/10.1038/s41598-019-40629-z
Publication status	Published - Dec 1 2019

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10.1038/s41598-019-40629-z

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title = "TACCO, a Database Connecting Transcriptome Alterations, Pathway Alterations and Clinical Outcomes in Cancers",

abstract = "Because of innumerable cancer sequencing projects, abundant transcriptome expression profiles together with survival data are available from the same patients. Although some expression signatures for prognosis or pathologic staging have been identified from these data, systematically discovering such kind of expression signatures remains a challenge. To address this, we developed TACCO (Transcriptome Alterations in CanCer Omnibus), a database for identifying differentially expressed genes and altered pathways in cancer. TACCO also reveals miRNA cooperative regulations and supports construction of models for prognosis. The resulting signatures have great potential for patient stratification and treatment decision-making in future clinical applications. TACCO is freely available at http://tacco.life.nctu.edu.tw/.",

author = "Chou, {Po Hao} and Liao, {Wei Chao} and Tsai, {Kuo Wang} and Chen, {Ku Chung} and Yu, {Jau Song} and Chen, {Ting Wen}",

note = "Funding Information: This study was supported by grants from the Ministry of Science and Technology, Taiwan (MOST-106-2311-B-182-005 and MOST-107-2311-B-182-001); the Chang Gung Memorial Hospital, Taiwan (CIRPD3B0013); and the “Molecular Medicine Research Center, Chang Gung University” from The Featured Areas Research Center Program within the framework of the Higher Education Sprout Project by the Ministry of Education (MOE) in Taiwan. Publisher Copyright: {\textcopyright} 2019, The Author(s).",

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doi = "10.1038/s41598-019-40629-z",

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AU - Chen, Ku Chung

AU - Yu, Jau Song

AU - Chen, Ting Wen

N1 - Funding Information: This study was supported by grants from the Ministry of Science and Technology, Taiwan (MOST-106-2311-B-182-005 and MOST-107-2311-B-182-001); the Chang Gung Memorial Hospital, Taiwan (CIRPD3B0013); and the “Molecular Medicine Research Center, Chang Gung University” from The Featured Areas Research Center Program within the framework of the Higher Education Sprout Project by the Ministry of Education (MOE) in Taiwan. Publisher Copyright: © 2019, The Author(s).

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N2 - Because of innumerable cancer sequencing projects, abundant transcriptome expression profiles together with survival data are available from the same patients. Although some expression signatures for prognosis or pathologic staging have been identified from these data, systematically discovering such kind of expression signatures remains a challenge. To address this, we developed TACCO (Transcriptome Alterations in CanCer Omnibus), a database for identifying differentially expressed genes and altered pathways in cancer. TACCO also reveals miRNA cooperative regulations and supports construction of models for prognosis. The resulting signatures have great potential for patient stratification and treatment decision-making in future clinical applications. TACCO is freely available at http://tacco.life.nctu.edu.tw/.

AB - Because of innumerable cancer sequencing projects, abundant transcriptome expression profiles together with survival data are available from the same patients. Although some expression signatures for prognosis or pathologic staging have been identified from these data, systematically discovering such kind of expression signatures remains a challenge. To address this, we developed TACCO (Transcriptome Alterations in CanCer Omnibus), a database for identifying differentially expressed genes and altered pathways in cancer. TACCO also reveals miRNA cooperative regulations and supports construction of models for prognosis. The resulting signatures have great potential for patient stratification and treatment decision-making in future clinical applications. TACCO is freely available at http://tacco.life.nctu.edu.tw/.

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TACCO, a Database Connecting Transcriptome Alterations, Pathway Alterations and Clinical Outcomes in Cancers

Abstract

ASJC Scopus subject areas

UN SDGs

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