TACCO, a Database Connecting Transcriptome Alterations, Pathway Alterations and Clinical Outcomes in Cancers

Po Hao Chou; Wei Chao Liao; Kuo Wang Tsai; Ku Chung Chen; Jau Song Yu; Ting Wen Chen

doi:10.1038/s41598-019-40629-z

TACCO, a Database Connecting Transcriptome Alterations, Pathway Alterations and Clinical Outcomes in Cancers

Po Hao Chou, Wei Chao Liao, Kuo Wang Tsai, Ku Chung Chen, Jau Song Yu, Ting Wen Chen

Research output: Contribution to journal › Article › peer-review

25 Citations (Scopus)

Abstract

Because of innumerable cancer sequencing projects, abundant transcriptome expression profiles together with survival data are available from the same patients. Although some expression signatures for prognosis or pathologic staging have been identified from these data, systematically discovering such kind of expression signatures remains a challenge. To address this, we developed TACCO (Transcriptome Alterations in CanCer Omnibus), a database for identifying differentially expressed genes and altered pathways in cancer. TACCO also reveals miRNA cooperative regulations and supports construction of models for prognosis. The resulting signatures have great potential for patient stratification and treatment decision-making in future clinical applications. TACCO is freely available at http://tacco.life.nctu.edu.tw/.

Original language	English
Article number	3877
Journal	Scientific Reports
Volume	9
Issue number	1
DOIs	https://doi.org/10.1038/s41598-019-40629-z
Publication status	Published - Dec 1 2019

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1038/s41598-019-40629-z

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abstract = "Because of innumerable cancer sequencing projects, abundant transcriptome expression profiles together with survival data are available from the same patients. Although some expression signatures for prognosis or pathologic staging have been identified from these data, systematically discovering such kind of expression signatures remains a challenge. To address this, we developed TACCO (Transcriptome Alterations in CanCer Omnibus), a database for identifying differentially expressed genes and altered pathways in cancer. TACCO also reveals miRNA cooperative regulations and supports construction of models for prognosis. The resulting signatures have great potential for patient stratification and treatment decision-making in future clinical applications. TACCO is freely available at http://tacco.life.nctu.edu.tw/.",

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AU - Chou, Po Hao

AU - Liao, Wei Chao

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AU - Chen, Ku Chung

AU - Yu, Jau Song

AU - Chen, Ting Wen

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TACCO, a Database Connecting Transcriptome Alterations, Pathway Alterations and Clinical Outcomes in Cancers

Abstract

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