T4 DNA topoisomerase: A new ATP-dependent enzyme essential for initiation of T4 bacteriophage DNA replication

Leroy F. Liu; Chung Cheng Liu; Bruce M. Alberts

doi:10.1038/281456a0

T4 DNA topoisomerase: A new ATP-dependent enzyme essential for initiation of T4 bacteriophage DNA replication

Leroy F. Liu
, Chung Cheng Liu
, Bruce M. Alberts

Research output: Contribution to journal › Article › peer-review

174 Citations (Scopus)

Abstract

A novel ATP-dependent DNA topoisomerase which makes reversible double-strand breaks in the DNA double helix has been purified to near homogeneity from T4 bacteriophage-infected Escherichia coli cells. Genetic data suggest that this activity is essential for initiating T4 DNA replication forks in vivo.

Original language	English
Pages (from-to)	456-461
Number of pages	6
Journal	Nature
Volume	281
Issue number	5731
DOIs	https://doi.org/10.1038/281456a0
Publication status	Published - 1979
Externally published	Yes

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@article{91437aff42904ef783eca63e40d7e461,

title = "T4 DNA topoisomerase: A new ATP-dependent enzyme essential for initiation of T4 bacteriophage DNA replication",

abstract = "A novel ATP-dependent DNA topoisomerase which makes reversible double-strand breaks in the DNA double helix has been purified to near homogeneity from T4 bacteriophage-infected Escherichia coli cells. Genetic data suggest that this activity is essential for initiating T4 DNA replication forks in vivo.",

author = "Liu, \{Leroy F.\} and Liu, \{Chung Cheng\} and Alberts, \{Bruce M.\}",

year = "1979",

doi = "10.1038/281456a0",

language = "English",

volume = "281",

pages = "456--461",

journal = "Nature",

issn = "0028-0836",

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AU - Liu, Leroy F.

AU - Liu, Chung Cheng

AU - Alberts, Bruce M.

PY - 1979

Y1 - 1979

N2 - A novel ATP-dependent DNA topoisomerase which makes reversible double-strand breaks in the DNA double helix has been purified to near homogeneity from T4 bacteriophage-infected Escherichia coli cells. Genetic data suggest that this activity is essential for initiating T4 DNA replication forks in vivo.

AB - A novel ATP-dependent DNA topoisomerase which makes reversible double-strand breaks in the DNA double helix has been purified to near homogeneity from T4 bacteriophage-infected Escherichia coli cells. Genetic data suggest that this activity is essential for initiating T4 DNA replication forks in vivo.

UR - https://www.scopus.com/pages/publications/0018731640

UR - https://www.scopus.com/pages/publications/0018731640#tab=citedBy

U2 - 10.1038/281456a0

DO - 10.1038/281456a0

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AN - SCOPUS:0018731640

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VL - 281

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EP - 461

JO - Nature

JF - Nature

IS - 5731

ER -

T4 DNA topoisomerase: A new ATP-dependent enzyme essential for initiation of T4 bacteriophage DNA replication

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