T4 DNA topoisomerase: A new ATP-dependent enzyme essential for initiation of T4 bacteriophage DNA replication

Leroy F. Liu, Chung Cheng Liu, Bruce M. Alberts

Research output: Contribution to journalArticlepeer-review

170 Citations (Scopus)

Abstract

A novel ATP-dependent DNA topoisomerase which makes reversible double-strand breaks in the DNA double helix has been purified to near homogeneity from T4 bacteriophage-infected Escherichia coli cells. Genetic data suggest that this activity is essential for initiating T4 DNA replication forks in vivo.

Original languageEnglish
Pages (from-to)456-461
Number of pages6
JournalNature
Volume281
Issue number5731
DOIs
Publication statusPublished - 1979
Externally publishedYes

ASJC Scopus subject areas

  • General

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