T4 DNA topoisomerase: A new ATP-dependent enzyme essential for initiation of T4 bacteriophage DNA replication

Leroy F. Liu; Chung Cheng Liu; Bruce M. Alberts

doi:10.1038/281456a0

T4 DNA topoisomerase: A new ATP-dependent enzyme essential for initiation of T4 bacteriophage DNA replication

Leroy F. Liu, Chung Cheng Liu, Bruce M. Alberts

Research output: Contribution to journal › Article › peer-review

172 Citations (Scopus)

Abstract

A novel ATP-dependent DNA topoisomerase which makes reversible double-strand breaks in the DNA double helix has been purified to near homogeneity from T4 bacteriophage-infected Escherichia coli cells. Genetic data suggest that this activity is essential for initiating T4 DNA replication forks in vivo.

Original language	English
Pages (from-to)	456-461
Number of pages	6
Journal	Nature
Volume	281
Issue number	5731
DOIs	https://doi.org/10.1038/281456a0
Publication status	Published - 1979
Externally published	Yes

ASJC Scopus subject areas

General

Access to Document

10.1038/281456a0

Cite this

@article{91437aff42904ef783eca63e40d7e461,

title = "T4 DNA topoisomerase: A new ATP-dependent enzyme essential for initiation of T4 bacteriophage DNA replication",

abstract = "A novel ATP-dependent DNA topoisomerase which makes reversible double-strand breaks in the DNA double helix has been purified to near homogeneity from T4 bacteriophage-infected Escherichia coli cells. Genetic data suggest that this activity is essential for initiating T4 DNA replication forks in vivo.",

author = "Liu, {Leroy F.} and Liu, {Chung Cheng} and Alberts, {Bruce M.}",

year = "1979",

doi = "10.1038/281456a0",

language = "English",

volume = "281",

pages = "456--461",

journal = "Nature",

issn = "0028-0836",

publisher = "Nature Research",

number = "5731",

}

TY - JOUR

T1 - T4 DNA topoisomerase

T2 - A new ATP-dependent enzyme essential for initiation of T4 bacteriophage DNA replication

AU - Liu, Leroy F.

AU - Liu, Chung Cheng

AU - Alberts, Bruce M.

PY - 1979

Y1 - 1979

N2 - A novel ATP-dependent DNA topoisomerase which makes reversible double-strand breaks in the DNA double helix has been purified to near homogeneity from T4 bacteriophage-infected Escherichia coli cells. Genetic data suggest that this activity is essential for initiating T4 DNA replication forks in vivo.

AB - A novel ATP-dependent DNA topoisomerase which makes reversible double-strand breaks in the DNA double helix has been purified to near homogeneity from T4 bacteriophage-infected Escherichia coli cells. Genetic data suggest that this activity is essential for initiating T4 DNA replication forks in vivo.

UR - http://www.scopus.com/inward/record.url?scp=0018731640&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0018731640&partnerID=8YFLogxK

U2 - 10.1038/281456a0

DO - 10.1038/281456a0

M3 - Article

C2 - 226889

AN - SCOPUS:0018731640

SN - 0028-0836

VL - 281

SP - 456

EP - 461

JO - Nature

JF - Nature

IS - 5731

ER -

T4 DNA topoisomerase: A new ATP-dependent enzyme essential for initiation of T4 bacteriophage DNA replication

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this