Abstract
Three patients with T-cell lymphoblastic lymphoma and peripheral blood eosinophilia are reported. At the time of diagnosis, all patients had lymphadenopathy, and one had a mediastinal mass. Lymph node biopsies revealed lymphoblastic lymphoma admixed with a variable number of mature eosinophils. Immunophenotypic studies demonstrated that each lymphoma had an immature T- cell immunophenotype. Bone marrow biopsies were hypercellular with myeloid hyperplasia and eosinophilia but were negative for lymphoma. All patients received multiagent chemotherapy; one patient achieved a complete remission, and two patients had partial remissions. All patients subsequently developed a myeloid malignancy. Two died of acute myeloid leukemia within 18 months of the diagnosis of lymphoblastic lymphoma. The third patient relapsed with a lymphoma that had histologic and immunophenotypic features of both T-cell lymphoblastic lymphoma and granulocytic sarcoma and also developed a poorly defined myeloproliferative disorder. These findings suggest that T-cell lymphoblastic lymphoma associated with eosinophilia may represent a distinct clinicopathologic entity with a high risk of subsequent myeloid neoplasia.
Original language | English |
---|---|
Pages (from-to) | 236-245 |
Number of pages | 10 |
Journal | American Journal of Surgical Pathology |
Volume | 16 |
Issue number | 3 |
DOIs | |
Publication status | Published - Jan 1 1992 |
Externally published | Yes |
Keywords
- Acute myeloid leukemia
- Eosinophilia
- Lymphoblastic lymphoma
- T-cell immunophenotype
ASJC Scopus subject areas
- Anatomy
- Surgery
- Pathology and Forensic Medicine