Systemic inflammatory response syndrome is an independent predictor of one-year mortality in patients with acute myocardial infarction

Wei Chieh Huang, Ruey Hsing Chou, Chun Chin Chang, Chien-Yu Hsu, Yuchen Ku, Hsiufen Huang, Yichieh Chen, Po Hsun Huang

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21 Citations (Scopus)


Background: Convincing evidence suggests that inflammatory biomarkers are associated with an increased risk among patients with acute myocardial infarction (AMI). However, the impact of systemic inflammatory response (SIRS) on one-year clinical outcomes remains uncertain. Herein we investigated the impact of SIRS on one-year mortality and major adverse cardiovascular events (MACE) in patients with AMI. Methods: We conducted a retrospective study that enrolled patients admitted due to AMI and who received coronary artery intervention from January 2012 to June 2014. SIRS was defined according to standard criteria as having two or more of the following: (1) body temperature < 36 or > 38 °C, (2) heart rate > 90 beats per minute, (3) respiratory rate > 20, or (4) white blood cell count < 4000/mm3 or > 12,000/mm3. The primary endpoint was one-year mortality. The secondary endpoint was a one-year MACE, including revascularization, AMI, and stroke. Results: A total of 330 AMI patients were enrolled in the study, and 121 study subjects (36.6%) met the SIRS criteria. AMI patients with SIRS on admission had significantly increased one-year all-cause mortality (control vs. SIRS: 21.1% vs. 33.1%, p = 0.026) and one-year MACE (35.9% vs. 53.7%, p = 0.022). Patients with SIRS had a higher incidence of one-year non-fatal myocardial infarction, but not non-fatal stroke. After multivariable adjustment, SIRS [hazard ratio (HR) = 1.773, 95% confidence interval (CI) = 1.097-2.886, p = 0.019] and age (HR = 1.038, 95% CI = 1.018-1.058, p < 0.001) were associated with enhanced risk of one-year mortality. Conclusions: This study revealed that AMI patients with SIRS on initial admission were associated with increased risk of one-year all-cause mortality. © 2017, Republic of China Society of Cardiology. All rights reserved.
Original languageEnglish
Pages (from-to)477-485
Number of pages9
JournalActa Cardiologica Sinica
Issue number5
Publication statusPublished - 2017
Externally publishedYes


  • Myocardial infarction
  • Systemic inflammatory response syndrome
  • acute heart infarction
  • aged
  • Article
  • atherosclerosis
  • body temperature
  • brain ischemia
  • breathing rate
  • clinical outcome
  • congestive heart failure
  • creatinine blood level
  • diabetes mellitus
  • electrocardiogram
  • follow up
  • heart infarction
  • heart left ventricle ejection fraction
  • human
  • inflammation
  • laboratory test
  • leukocyte
  • leukocyte count
  • long term care
  • major clinical study
  • male
  • mortality
  • retrospective study
  • systemic inflammatory response syndrome
  • target vessel revascularization


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