Systematic review of nutrition supplements in chronic kidney diseases: A grade approach

Pei Chin Lin, Chu Lin Chou, Shih Hsiang Ou, Te Chao Fang, Jin Shuen Chen

Research output: Contribution to journalReview articlepeer-review

11 Citations (Scopus)


Chronic kidney disease (CKD) is cumulative worldwide and an increasing public health issue. Aside from the widely known protein restriction and medical therapy, less evident is the renal protection of nutrition supplements in CKD patients. This systematic review (SR), using a Grading of Recommendations Assessment, Development, and Evaluation (GRADE) approach, aims to summarize and quantify evidence about the prevention effects of vitamin D and analogues, omega-3 polyunsaturated fatty acid (omega-3 PUFA), dietary fiber, coenzyme Q10 (CoQ10), and biotics on CKD progression. This study was conducted following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement to examine SRs and/or meta-analysis of clinical controlled trials identified from PubMed, Embase, and the Cochrane Li;brary. Finally, seventeen SRs were included in the qualitative analysis. The beneficial effects of these nutrition supplements in CKD patients mostly seem to be at low to very low evidence on proteinuria, kidney function, and inflammations and did not appear to improve CKD prognosis. The recommendation of nutrition supplements in CKD patients needs to discuss with physicians and consider the benefits over the adverse effects. Longer follow-up of larger randomized trials is necessary to clarify the benefits of nutrition supplements in CKD patients.

Original languageEnglish
Article number469
Pages (from-to)1-21
Number of pages21
Issue number2
Publication statusPublished - Feb 2021


  • Biotics
  • Chronic kidney disease
  • Coenzyme Q10
  • Dietary fiber
  • Omega-3 polyunsaturated fatty acid
  • Vitamin D and analogues

ASJC Scopus subject areas

  • Food Science
  • Nutrition and Dietetics


Dive into the research topics of 'Systematic review of nutrition supplements in chronic kidney diseases: A grade approach'. Together they form a unique fingerprint.

Cite this