Systematic assessment of the tagging polymorphisms of the COL1A1 gene for high myopia

Chung Ling Liang, Kuo Sheng Hung, Yueh Ying Tsai, Wansu Chang, Hsin Shih Wang, Suh Hang Hank Juo

Research output: Contribution to journalArticlepeer-review

32 Citations (Scopus)


Reduced scleral collagen accumulation has been found in the development of myopia. Single nucleotide polymorphisms (SNPs) at the type I collagen α-1 gene (COL1A1) may cause different susceptibilities to myopia. We conducted a case-control study to systematically examine COL1A1 as a candidate gene for high myopia. A case was defined as spherical refraction ≤-6 D and control ≥-1.5 D. The study comprised 471 cases and 623 controls, and ten tagging SNPs were genotyped. None of the SNPs reached the significant level of 0.05. Subset analysis on cases with a strong family history did not demonstrate significant results. We could not find an interaction between gene and near work. Exploratory analyses by changing the cutoff values to re-define cases and controls did not improve the results. Haplotype analysis did not yield significant association with myopia. This study failed to demonstrate COL1A1 as a significant risk factor for high myopia.

Original languageEnglish
Pages (from-to)374-377
Number of pages4
JournalJournal of Human Genetics
Issue number4
Publication statusPublished - Apr 2007


  • COL1A1
  • Case-control study
  • Haplotype
  • Myopia
  • SNP

ASJC Scopus subject areas

  • Genetics(clinical)
  • Genetics


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