Synthesis of the self‐complementary RNA‐DNA hybrid:R(GCG)D(TATACGC)

C. A.A. van Boeckel, G. A. van der Marel, G. Wille, H. Westerink, A. H.J. Wang, J. R. Mellema, C. Altona, J. H. van Boom

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)


A nucleic acid fragment containing a RNA trimer and a DNA heptamer wich are linked by a 3′‐5′‐internucleotide phosphodiester bond has been synthesized by a phosphotriester approach. The sequence of the nucleosides is such that they will form a self‐complementary double‐helical fragment which may serve as a probe to get more insight into the process of discontinuous DNA replication.

Original languageEnglish
Pages (from-to)389-390
Number of pages2
JournalRecueil des Travaux Chimiques des Pays‐Bas
Issue number10
Publication statusPublished - 1981
Externally publishedYes

ASJC Scopus subject areas

  • General Chemistry


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