Synthesis of mesoporous silica nanoparticles

Si-Han Wu, Chung Yuan Mou, Hong Ping Lin

Research output: Contribution to journalArticlepeer-review

1164 Citations (Scopus)


Good control of the morphology, particle size, uniformity and dispersity of mesoporous silica nanoparticles (MSNs) is of increasing importance to their use in catalyst, adsorption, polymer filler, optical devices, bio-imaging, drug delivery, and biomedical applications. This review discusses different synthesis methodologies to prepare well-dispersed MSNs and hollow silica nanoparticles (HSNs) with tunable dimensions ranging from a few to hundreds of nanometers of different mesostructures. The methods include fast self-assembly, soft and hard templating, a modified Stöber method, dissolving-reconstruction and modified aerogel approaches. In practical applications, the MSNs prepared by these methods demonstrate good potential for use in high-performance catalysis, antireflection coating, transparent polymer-MSNs nanocomposites, drug-release and theranostic systems.

Original languageEnglish
Pages (from-to)3862-3875
Number of pages14
JournalChemical Society Reviews
Issue number9
Publication statusPublished - May 7 2013
Externally publishedYes

ASJC Scopus subject areas

  • Chemistry(all)


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