Synthesis of biocompatible TiZr-based bulk metallic glass foams for bio-implant application

V. T. Nguyen; T. H. Li; S. M. Song; Y. C. Liao; P. H. Tsai; P. C. Wong; V. C. Nguyen; J. S.C. Jang

doi:10.1016/j.matlet.2019.126650

Synthesis of biocompatible TiZr-based bulk metallic glass foams for bio-implant application

V. T. Nguyen, T. H. Li, S. M. Song, Y. C. Liao, P. H. Tsai, P. C. Wong, V. C. Nguyen, J. S.C. Jang

Research output: Contribution to journal › Article › peer-review

11 Citations (Scopus)

Abstract

A series of porous toxic-element-free TiZr-based bulk metallic glass foams (BMGFs) with porosities ranging from 2.0% to 38.9% were fabricated by hot-pressing method. The results indicated that the BMGFs with pore sizes of 100–300 μm exhibit relatively good mechanical properties, Young's moduli ranging from 5.8 to 56.4 GPa and compressive strength from 33 to 979 MPa which well match the properties of human bone. In in vitro tests, the TiZr-based BMGFs with porosities of 12.7% and 34.8% showed non-cytotoxicity and high extracellular calcium deposition. Owing to the excellent combination of suitable porosities, consistent mechanical properties, and high biocompatibility, the TiZr-based BMGFs are promising candidates for use in bio-implant applications from the viewpoints of avoiding stress shielding and bio-unfriendly symptoms in the human body.

Original language	English
Article number	126650
Journal	Materials Letters
Volume	256
DOIs	https://doi.org/10.1016/j.matlet.2019.126650
Publication status	Published - Dec 2019

Keywords

Amorphous materials
Biomaterials
Hot-pressing
Mechanical property
Porous materials

ASJC Scopus subject areas

General Materials Science
Condensed Matter Physics
Mechanics of Materials
Mechanical Engineering

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title = "Synthesis of biocompatible TiZr-based bulk metallic glass foams for bio-implant application",

abstract = "A series of porous toxic-element-free TiZr-based bulk metallic glass foams (BMGFs) with porosities ranging from 2.0% to 38.9% were fabricated by hot-pressing method. The results indicated that the BMGFs with pore sizes of 100–300 μm exhibit relatively good mechanical properties, Young's moduli ranging from 5.8 to 56.4 GPa and compressive strength from 33 to 979 MPa which well match the properties of human bone. In in vitro tests, the TiZr-based BMGFs with porosities of 12.7% and 34.8% showed non-cytotoxicity and high extracellular calcium deposition. Owing to the excellent combination of suitable porosities, consistent mechanical properties, and high biocompatibility, the TiZr-based BMGFs are promising candidates for use in bio-implant applications from the viewpoints of avoiding stress shielding and bio-unfriendly symptoms in the human body.",

keywords = "Amorphous materials, Biomaterials, Hot-pressing, Mechanical property, Porous materials",

author = "Nguyen, {V. T.} and Li, {T. H.} and Song, {S. M.} and Liao, {Y. C.} and Tsai, {P. H.} and Wong, {P. C.} and Nguyen, {V. C.} and Jang, {J. S.C.}",

note = "Funding Information: The authors gratefully acknowledge the sponsorship provided by the Ministry of Science and Technology of ROC under the projects MOST105-2221-E-008 -025 -MY3 and MOST 106-3114-E-110-003. In addition, the authors gratefully acknowledge the help from the Precision Instrument Center of Engineering College, NCU, for the SEM and TEM characterizations and Wallace Academic Editing for revising this manuscript. Publisher Copyright: {\textcopyright} 2019 Elsevier B.V.",

year = "2019",

month = dec,

doi = "10.1016/j.matlet.2019.126650",

language = "English",

volume = "256",

journal = "Materials Letters",

issn = "0167-577X",

publisher = "Elsevier B.V.",

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TY - JOUR

T1 - Synthesis of biocompatible TiZr-based bulk metallic glass foams for bio-implant application

AU - Nguyen, V. T.

AU - Li, T. H.

AU - Song, S. M.

AU - Liao, Y. C.

AU - Tsai, P. H.

AU - Wong, P. C.

AU - Nguyen, V. C.

AU - Jang, J. S.C.

N1 - Funding Information: The authors gratefully acknowledge the sponsorship provided by the Ministry of Science and Technology of ROC under the projects MOST105-2221-E-008 -025 -MY3 and MOST 106-3114-E-110-003. In addition, the authors gratefully acknowledge the help from the Precision Instrument Center of Engineering College, NCU, for the SEM and TEM characterizations and Wallace Academic Editing for revising this manuscript. Publisher Copyright: © 2019 Elsevier B.V.

PY - 2019/12

Y1 - 2019/12

N2 - A series of porous toxic-element-free TiZr-based bulk metallic glass foams (BMGFs) with porosities ranging from 2.0% to 38.9% were fabricated by hot-pressing method. The results indicated that the BMGFs with pore sizes of 100–300 μm exhibit relatively good mechanical properties, Young's moduli ranging from 5.8 to 56.4 GPa and compressive strength from 33 to 979 MPa which well match the properties of human bone. In in vitro tests, the TiZr-based BMGFs with porosities of 12.7% and 34.8% showed non-cytotoxicity and high extracellular calcium deposition. Owing to the excellent combination of suitable porosities, consistent mechanical properties, and high biocompatibility, the TiZr-based BMGFs are promising candidates for use in bio-implant applications from the viewpoints of avoiding stress shielding and bio-unfriendly symptoms in the human body.

AB - A series of porous toxic-element-free TiZr-based bulk metallic glass foams (BMGFs) with porosities ranging from 2.0% to 38.9% were fabricated by hot-pressing method. The results indicated that the BMGFs with pore sizes of 100–300 μm exhibit relatively good mechanical properties, Young's moduli ranging from 5.8 to 56.4 GPa and compressive strength from 33 to 979 MPa which well match the properties of human bone. In in vitro tests, the TiZr-based BMGFs with porosities of 12.7% and 34.8% showed non-cytotoxicity and high extracellular calcium deposition. Owing to the excellent combination of suitable porosities, consistent mechanical properties, and high biocompatibility, the TiZr-based BMGFs are promising candidates for use in bio-implant applications from the viewpoints of avoiding stress shielding and bio-unfriendly symptoms in the human body.

KW - Amorphous materials

KW - Biomaterials

KW - Hot-pressing

KW - Mechanical property

KW - Porous materials

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Synthesis of biocompatible TiZr-based bulk metallic glass foams for bio-implant application

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Keywords

ASJC Scopus subject areas

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