Synthesis, Lipid Peroxidation and Cytotoxic Evaluation of 10-Substituted 1,5-Dichloro-9(10H)-anthracenone Derivatives

Hsu-Shan Huang

Synthesis, Lipid Peroxidation and Cytotoxic Evaluation of 10-Substituted 1,5-Dichloro-9(10H)-anthracenone Derivatives

Research output: Patent

Abstract

The present invention is the synthesis of a series of 1,5-dichloro-9(10H)-anthracenones bearing O-linked and N-linked substituents in the 10-position. These compounds were evaluated for their ability to inhibit the growth of the human oral epidermoid carcinoma cells (KB cell line), human cervical carcinoma cells of ME 180 (GBM 8401) and Chinese hamster ovary cells (CHO), respectively. In addition, redox property of the compounds for inhibition of lipid peroxidation in model membranes was determined.

Original language	English
Publication status	Published - 2003

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title = "Synthesis, Lipid Peroxidation and Cytotoxic Evaluation of 10-Substituted 1,5-Dichloro-9(10H)-anthracenone Derivatives",

abstract = "The present invention is the synthesis of a series of 1,5-dichloro-9(10H)-anthracenones bearing O-linked and N-linked substituents in the 10-position. These compounds were evaluated for their ability to inhibit the growth of the human oral epidermoid carcinoma cells (KB cell line), human cervical carcinoma cells of ME 180 (GBM 8401) and Chinese hamster ovary cells (CHO), respectively. In addition, redox property of the compounds for inhibition of lipid peroxidation in model membranes was determined.",

author = "Hsu-Shan Huang",

year = "2003",

language = "English",

type = "Patent",

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TY - PAT

T1 - Synthesis, Lipid Peroxidation and Cytotoxic Evaluation of 10-Substituted 1,5-Dichloro-9(10H)-anthracenone Derivatives

AU - Huang, Hsu-Shan

PY - 2003

Y1 - 2003

N2 - The present invention is the synthesis of a series of 1,5-dichloro-9(10H)-anthracenones bearing O-linked and N-linked substituents in the 10-position. These compounds were evaluated for their ability to inhibit the growth of the human oral epidermoid carcinoma cells (KB cell line), human cervical carcinoma cells of ME 180 (GBM 8401) and Chinese hamster ovary cells (CHO), respectively. In addition, redox property of the compounds for inhibition of lipid peroxidation in model membranes was determined.

AB - The present invention is the synthesis of a series of 1,5-dichloro-9(10H)-anthracenones bearing O-linked and N-linked substituents in the 10-position. These compounds were evaluated for their ability to inhibit the growth of the human oral epidermoid carcinoma cells (KB cell line), human cervical carcinoma cells of ME 180 (GBM 8401) and Chinese hamster ovary cells (CHO), respectively. In addition, redox property of the compounds for inhibition of lipid peroxidation in model membranes was determined.

UR - https://www.google.com/patents/US6596774?dq=Synthesis,+Lipid+Peroxidation+and+Cytotoxic+Evaluation+of+10-Substituted+1,5-Dichloro-9(10H)-anthracenone+Derivatives&hl=zh-TW&sa=X&ved=0ahUKEwidm_3czYHOAhWMj5QKHde1AngQ6AEIHjAA

M3 - Patent

ER -

Synthesis, Lipid Peroxidation and Cytotoxic Evaluation of 10-Substituted 1,5-Dichloro-9(10H)-anthracenone Derivatives

Abstract

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