Synthesis and biological evaluation of 4-aroyl-6,7,8-trimethoxyquinolines as a novel class of anticancer agents

Cheng Chih Hsieh; Hsueh Yun Lee; Chih Ying Nien; Ching Chuan Kuo; Chi Yen Chang; Jang Yang Chang; Jing Ping Liou

doi:10.3390/molecules16032274

Synthesis and biological evaluation of 4-aroyl-6,7,8-trimethoxyquinolines as a novel class of anticancer agents

Cheng Chih Hsieh, Hsueh Yun Lee, Chih Ying Nien, Ching Chuan Kuo, Chi Yen Chang, Jang Yang Chang, Jing Ping Liou

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

A series of 2-aroyl and 2-aryl-5,6,7-trimethoxyquinoline and 4-aroyl-6,7,8-trimethoxyquinoline combretastatin analogs were synthesized and evaluated for their potential anticancer activity. The 4-aroylquinoline 11 inhibited the growth of the human cancer cells lines KB, HT-29, and MKN45, as well as the three human resistant cancer cell lines KB-vin10, KB-S15, and KB-7D, with IC50 values of 217, 327, 239, 246, 213, and 252 nM, respectively.

Original language	English
Pages (from-to)	2274-2284
Number of pages	11
Journal	Molecules
Volume	16
Issue number	3
DOIs	https://doi.org/10.3390/molecules16032274
Publication status	Published - Mar 2011

Keywords

Antiproliferative activity
Combretastatin analogs
Multidrug-resistant
Trimethoxyquinolines

ASJC Scopus subject areas

Analytical Chemistry
Chemistry (miscellaneous)
Molecular Medicine
Pharmaceutical Science
Drug Discovery
Physical and Theoretical Chemistry
Organic Chemistry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3390/molecules16032274

Cite this

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title = "Synthesis and biological evaluation of 4-aroyl-6,7,8-trimethoxyquinolines as a novel class of anticancer agents",

abstract = "A series of 2-aroyl and 2-aryl-5,6,7-trimethoxyquinoline and 4-aroyl-6,7,8-trimethoxyquinoline combretastatin analogs were synthesized and evaluated for their potential anticancer activity. The 4-aroylquinoline 11 inhibited the growth of the human cancer cells lines KB, HT-29, and MKN45, as well as the three human resistant cancer cell lines KB-vin10, KB-S15, and KB-7D, with IC50 values of 217, 327, 239, 246, 213, and 252 nM, respectively.",

keywords = "Antiproliferative activity, Combretastatin analogs, Multidrug-resistant, Trimethoxyquinolines",

author = "Hsieh, {Cheng Chih} and Lee, {Hsueh Yun} and Nien, {Chih Ying} and Kuo, {Ching Chuan} and Chang, {Chi Yen} and Chang, {Jang Yang} and Liou, {Jing Ping}",

year = "2011",

month = mar,

doi = "10.3390/molecules16032274",

language = "English",

volume = "16",

pages = "2274--2284",

journal = "Molecules",

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T1 - Synthesis and biological evaluation of 4-aroyl-6,7,8-trimethoxyquinolines as a novel class of anticancer agents

AU - Hsieh, Cheng Chih

AU - Lee, Hsueh Yun

AU - Nien, Chih Ying

AU - Kuo, Ching Chuan

AU - Chang, Chi Yen

AU - Chang, Jang Yang

AU - Liou, Jing Ping

PY - 2011/3

Y1 - 2011/3

N2 - A series of 2-aroyl and 2-aryl-5,6,7-trimethoxyquinoline and 4-aroyl-6,7,8-trimethoxyquinoline combretastatin analogs were synthesized and evaluated for their potential anticancer activity. The 4-aroylquinoline 11 inhibited the growth of the human cancer cells lines KB, HT-29, and MKN45, as well as the three human resistant cancer cell lines KB-vin10, KB-S15, and KB-7D, with IC50 values of 217, 327, 239, 246, 213, and 252 nM, respectively.

AB - A series of 2-aroyl and 2-aryl-5,6,7-trimethoxyquinoline and 4-aroyl-6,7,8-trimethoxyquinoline combretastatin analogs were synthesized and evaluated for their potential anticancer activity. The 4-aroylquinoline 11 inhibited the growth of the human cancer cells lines KB, HT-29, and MKN45, as well as the three human resistant cancer cell lines KB-vin10, KB-S15, and KB-7D, with IC50 values of 217, 327, 239, 246, 213, and 252 nM, respectively.

KW - Antiproliferative activity

KW - Combretastatin analogs

KW - Multidrug-resistant

KW - Trimethoxyquinolines

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DO - 10.3390/molecules16032274

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Synthesis and biological evaluation of 4-aroyl-6,7,8-trimethoxyquinolines as a novel class of anticancer agents

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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