SYNTHESIS AND BIOLOGICAL ACTIVITY OF HUMAN β‐ENDORPHIN ANALOGS WITH DISULFIDE BRIDGES

JAMES BLAKE; WEN‐CHANG ‐C CHANG; CHOH HAO LI

doi:10.1111/j.1399-3011.1979.tb01933.x

SYNTHESIS AND BIOLOGICAL ACTIVITY OF HUMAN β‐ENDORPHIN ANALOGS WITH DISULFIDE BRIDGES

JAMES BLAKE, WEN‐CHANG ‐C CHANG, CHOH HAO LI

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Abstract

Three analogs of human β‐endorphin containing internal cystine bridges have been synthesized and their biological activities have been determined. It was found that the analogs with disulfide bridges between positions 17 and 26 or 11 and 26 retained full opiate activity as estimated by guinea ileum assay, whereas the analog with a cystine bridge between positions 7 and 26 showed reduced opiate activity. None of the analogs retained significant immunoactivity as revealed by radioimmunoassay.

Original language	English
Pages (from-to)	275-280
Number of pages	6
Journal	International Journal of Peptide and Protein Research
Volume	14
Issue number	3
DOIs	https://doi.org/10.1111/j.1399-3011.1979.tb01933.x
Publication status	Published - Jan 1 1979
Externally published	Yes

Keywords

disulfide bridges
opiate activity
radioimmunoactivity
β‐endorphin

ASJC Scopus subject areas

Biochemistry

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10.1111/j.1399-3011.1979.tb01933.x

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abstract = "Three analogs of human β‐endorphin containing internal cystine bridges have been synthesized and their biological activities have been determined. It was found that the analogs with disulfide bridges between positions 17 and 26 or 11 and 26 retained full opiate activity as estimated by guinea ileum assay, whereas the analog with a cystine bridge between positions 7 and 26 showed reduced opiate activity. None of the analogs retained significant immunoactivity as revealed by radioimmunoassay.",

keywords = "disulfide bridges, opiate activity, radioimmunoactivity, β‐endorphin",

author = "JAMES BLAKE and CHANG, {WEN‐CHANG ‐C} and LI, {CHOH HAO}",

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AU - LI, CHOH HAO

PY - 1979/1/1

Y1 - 1979/1/1

N2 - Three analogs of human β‐endorphin containing internal cystine bridges have been synthesized and their biological activities have been determined. It was found that the analogs with disulfide bridges between positions 17 and 26 or 11 and 26 retained full opiate activity as estimated by guinea ileum assay, whereas the analog with a cystine bridge between positions 7 and 26 showed reduced opiate activity. None of the analogs retained significant immunoactivity as revealed by radioimmunoassay.

AB - Three analogs of human β‐endorphin containing internal cystine bridges have been synthesized and their biological activities have been determined. It was found that the analogs with disulfide bridges between positions 17 and 26 or 11 and 26 retained full opiate activity as estimated by guinea ileum assay, whereas the analog with a cystine bridge between positions 7 and 26 showed reduced opiate activity. None of the analogs retained significant immunoactivity as revealed by radioimmunoassay.

KW - disulfide bridges

KW - opiate activity

KW - radioimmunoactivity

KW - β‐endorphin

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SYNTHESIS AND BIOLOGICAL ACTIVITY OF HUMAN β‐ENDORPHIN ANALOGS WITH DISULFIDE BRIDGES

Abstract

Keywords

ASJC Scopus subject areas

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