Synthesis and anti-HIV activity of dibenzylbutyrolactone lignans

Li Ming Yang; Shwu Jiuan Lin; Tsang Hsiung Yang; Kuo Hsiung Lee

doi:10.1016/0960-894X(96)00158-8

Synthesis and anti-HIV activity of dibenzylbutyrolactone lignans

Li Ming Yang
, Shwu Jiuan Lin
, Tsang Hsiung Yang
, Kuo Hsiung Lee

Research output: Contribution to journal › Article › peer-review

40 Citations (Scopus)

Abstract

Five optically active dibenzylbutyrolactone lignans were synthesized through a lipase-catalyzed transesterification route and evaluated for their inhibitory activity against HIV-1 replication in acutely infected H9 cells. Compounds 1 and 2 demonstrated anti-HIV replication activity with an EC₅₀ values of 2.2 and 0.16 μg/ml and a therapeutic index values of 9.1 and 5, respectively. Structure-antiviral activity relationships are discussed.

Original language	English
Pages (from-to)	941-944
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	6
Issue number	8
DOIs	https://doi.org/10.1016/0960-894X(96)00158-8
Publication status	Published - Apr 23 1996

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

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10.1016/0960-894X(96)00158-8

Cite this

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abstract = "Five optically active dibenzylbutyrolactone lignans were synthesized through a lipase-catalyzed transesterification route and evaluated for their inhibitory activity against HIV-1 replication in acutely infected H9 cells. Compounds 1 and 2 demonstrated anti-HIV replication activity with an EC50 values of 2.2 and 0.16 μg/ml and a therapeutic index values of 9.1 and 5, respectively. Structure-antiviral activity relationships are discussed.",

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AU - Yang, Li Ming

AU - Lin, Shwu Jiuan

AU - Yang, Tsang Hsiung

AU - Lee, Kuo Hsiung

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Y1 - 1996/4/23

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AB - Five optically active dibenzylbutyrolactone lignans were synthesized through a lipase-catalyzed transesterification route and evaluated for their inhibitory activity against HIV-1 replication in acutely infected H9 cells. Compounds 1 and 2 demonstrated anti-HIV replication activity with an EC50 values of 2.2 and 0.16 μg/ml and a therapeutic index values of 9.1 and 5, respectively. Structure-antiviral activity relationships are discussed.

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ER -

Synthesis and anti-HIV activity of dibenzylbutyrolactone lignans

Abstract

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ASJC Scopus subject areas

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