Synthesis and anti-HIV activity of dibenzylbutyrolactone lignans

Li Ming Yang; Shwu Jiuan Lin; Tsang Hsiung Yang; Kuo Hsiung Lee

doi:10.1016/0960-894X(96)00158-8

Synthesis and anti-HIV activity of dibenzylbutyrolactone lignans

Li Ming Yang, Shwu Jiuan Lin, Tsang Hsiung Yang, Kuo Hsiung Lee

Research output: Contribution to journal › Article › peer-review

40 Citations (Scopus)

Abstract

Five optically active dibenzylbutyrolactone lignans were synthesized through a lipase-catalyzed transesterification route and evaluated for their inhibitory activity against HIV-1 replication in acutely infected H9 cells. Compounds 1 and 2 demonstrated anti-HIV replication activity with an EC₅₀ values of 2.2 and 0.16 μg/ml and a therapeutic index values of 9.1 and 5, respectively. Structure-antiviral activity relationships are discussed.

Original language	English
Pages (from-to)	941-944
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	6
Issue number	8
DOIs	https://doi.org/10.1016/0960-894X(96)00158-8
Publication status	Published - Apr 23 1996

ASJC Scopus subject areas

Drug Discovery
Molecular Medicine
Molecular Biology
Biochemistry
Clinical Biochemistry
Pharmaceutical Science
Organic Chemistry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/0960-894X(96)00158-8

Cite this

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abstract = "Five optically active dibenzylbutyrolactone lignans were synthesized through a lipase-catalyzed transesterification route and evaluated for their inhibitory activity against HIV-1 replication in acutely infected H9 cells. Compounds 1 and 2 demonstrated anti-HIV replication activity with an EC50 values of 2.2 and 0.16 μg/ml and a therapeutic index values of 9.1 and 5, respectively. Structure-antiviral activity relationships are discussed.",

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AU - Lin, Shwu Jiuan

AU - Yang, Tsang Hsiung

AU - Lee, Kuo Hsiung

PY - 1996/4/23

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AB - Five optically active dibenzylbutyrolactone lignans were synthesized through a lipase-catalyzed transesterification route and evaluated for their inhibitory activity against HIV-1 replication in acutely infected H9 cells. Compounds 1 and 2 demonstrated anti-HIV replication activity with an EC50 values of 2.2 and 0.16 μg/ml and a therapeutic index values of 9.1 and 5, respectively. Structure-antiviral activity relationships are discussed.

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Synthesis and anti-HIV activity of dibenzylbutyrolactone lignans

Abstract

ASJC Scopus subject areas

UN SDGs

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