Synthesis and anti-HIV activity of dibenzylbutyrolactone lignans

Li Ming Yang, Shwu Jiuan Lin, Tsang Hsiung Yang, Kuo Hsiung Lee

Research output: Contribution to journalArticlepeer-review

40 Citations (Scopus)


Five optically active dibenzylbutyrolactone lignans were synthesized through a lipase-catalyzed transesterification route and evaluated for their inhibitory activity against HIV-1 replication in acutely infected H9 cells. Compounds 1 and 2 demonstrated anti-HIV replication activity with an EC50 values of 2.2 and 0.16 μg/ml and a therapeutic index values of 9.1 and 5, respectively. Structure-antiviral activity relationships are discussed.

Original languageEnglish
Pages (from-to)941-944
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Issue number8
Publication statusPublished - Apr 23 1996

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Organic Chemistry
  • Drug Discovery
  • Pharmaceutical Science


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