TY - JOUR
T1 - Sustained release of 5-FU from Poloxamer gels interpenetrated by crosslinking chitosan network
AU - Chung, Tze Wen
AU - Lin, Shyr Yi
AU - Liu, Der Zen
AU - Tyan, Yu Chang
AU - Yang, Juin Sen
PY - 2009/12/1
Y1 - 2009/12/1
N2 - This study investigates in vitro the drug delivery characteristics of new thermo-sensitive gels, P-CS/GA gels, in which a chitosan (CS) network is crosslinked with various concentrations of glutaraldehyde (GA) that interpenetrates Poloxamer (P) gels. The results indicate that the swelling ratios of all P-CS/GA gels are markedly superior to those of non-swelling P and P-CS gels. For example, P-CS/GA (0.1 wt.%) gels have swelling ratios of 13.2 ± 1.0, which are maintained for approximately 18 h in water at 37 °C. In vitro releases of 5-FU from P-CS/GA (0.1 wt.%) gels had significantly lower initial burst release (P <0.01) and lasted much longer than those from gels without a CS network. For example, the duration of release of 5-FU was in a significantly sustained manner for up to 52 h, which was about 10 times or longer than the period of delivery using P or P-CS gels. The release of drugs from gels with an interpenetrating CS network could be modeled by Fickian diffusion; the characteristic constant 'k' of drug-gel systems decreased as increasing GA concentrations in the P-CS/GA gels, and increasing the viscosities of the P, P-CS and P-CS/GA solutions.
AB - This study investigates in vitro the drug delivery characteristics of new thermo-sensitive gels, P-CS/GA gels, in which a chitosan (CS) network is crosslinked with various concentrations of glutaraldehyde (GA) that interpenetrates Poloxamer (P) gels. The results indicate that the swelling ratios of all P-CS/GA gels are markedly superior to those of non-swelling P and P-CS gels. For example, P-CS/GA (0.1 wt.%) gels have swelling ratios of 13.2 ± 1.0, which are maintained for approximately 18 h in water at 37 °C. In vitro releases of 5-FU from P-CS/GA (0.1 wt.%) gels had significantly lower initial burst release (P <0.01) and lasted much longer than those from gels without a CS network. For example, the duration of release of 5-FU was in a significantly sustained manner for up to 52 h, which was about 10 times or longer than the period of delivery using P or P-CS gels. The release of drugs from gels with an interpenetrating CS network could be modeled by Fickian diffusion; the characteristic constant 'k' of drug-gel systems decreased as increasing GA concentrations in the P-CS/GA gels, and increasing the viscosities of the P, P-CS and P-CS/GA solutions.
KW - 5-FU
KW - Drug delivery
KW - Hydrogels
KW - Interpenetrating CS network
KW - Poloxamer
UR - http://www.scopus.com/inward/record.url?scp=70350347757&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=70350347757&partnerID=8YFLogxK
U2 - 10.1016/j.ijpharm.2009.07.035
DO - 10.1016/j.ijpharm.2009.07.035
M3 - Article
C2 - 19666095
AN - SCOPUS:70350347757
SN - 0378-5173
VL - 382
SP - 39
EP - 44
JO - International Journal of Pharmaceutics
JF - International Journal of Pharmaceutics
IS - 1-2
ER -