Survivin - biology and potential as a therapeutic target in oncology

Chun Hei Antonio Cheung; Chien Chang Huang; Fang Ying Tsai; Jane Ying Chieh Lee; Siao Muk Cheng; Yung Chieh Chang; Yi Chun Huang; Shang Hung Chen; Jang Yang Chang

doi:10.2147/OTT.S33374

Survivin - biology and potential as a therapeutic target in oncology

Chun Hei Antonio Cheung
, Chien Chang Huang
, Fang Ying Tsai
, Jane Ying Chieh Lee
, Siao Muk Cheng
, Yung Chieh Chang
, Yi Chun Huang
, Shang Hung Chen
, Jang Yang Chang

Research output: Contribution to journal › Review article › peer-review

137 Citations (Scopus)

Abstract

Survivin is a member of the inhibitor-of-apoptosis proteins (IAPs) family; its overexpression has been widely demonstrated to occur in various types of cancer. Overexpression of survivin also correlates with tumor progression and induces anticancer drug resistance. Interestingly, recent studies reveal that survivin exhibits multiple pro-mitotic and anti-apoptotic functions; the differential functions of survivin seem to be caused by differential subcellular localization, phosphorylation, and acetylation of this molecule. In this review, the complex expression regulations and post-translational modifications of survivin are discussed. This review also discusses how recent discoveries improve our understanding of survivin biology and also create opportunities for developing differential-functioned survivin-targeted therapy. Databases such as PubMed, Scopus® (Elsevier, New York, NY, USA), and SciFinder® (CAS, Columbus, OH, USA) were used to search for literature in the preparation of this review.

Original language	English
Pages (from-to)	1453-1462
Number of pages	10
Journal	OncoTargets and Therapy
Volume	6
DOIs	https://doi.org/10.2147/OTT.S33374
Publication status	Published - 2013
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

BIRC5
Caspase-9
DIABLO
IAP
Samc
Survivin
XIAP

ASJC Scopus subject areas

Oncology
Pharmacology (medical)

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10.2147/OTT.S33374

Cite this

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title = "Survivin - biology and potential as a therapeutic target in oncology",

abstract = "Survivin is a member of the inhibitor-of-apoptosis proteins (IAPs) family; its overexpression has been widely demonstrated to occur in various types of cancer. Overexpression of survivin also correlates with tumor progression and induces anticancer drug resistance. Interestingly, recent studies reveal that survivin exhibits multiple pro-mitotic and anti-apoptotic functions; the differential functions of survivin seem to be caused by differential subcellular localization, phosphorylation, and acetylation of this molecule. In this review, the complex expression regulations and post-translational modifications of survivin are discussed. This review also discusses how recent discoveries improve our understanding of survivin biology and also create opportunities for developing differential-functioned survivin-targeted therapy. Databases such as PubMed, Scopus{\textregistered} (Elsevier, New York, NY, USA), and SciFinder{\textregistered} (CAS, Columbus, OH, USA) were used to search for literature in the preparation of this review.",

keywords = "BIRC5, Caspase-9, DIABLO, IAP, Samc, Survivin, XIAP",

author = "\{Antonio Cheung\}, \{Chun Hei\} and Huang, \{Chien Chang\} and Tsai, \{Fang Ying\} and Lee, \{Jane Ying Chieh\} and Cheng, \{Siao Muk\} and Chang, \{Yung Chieh\} and Huang, \{Yi Chun\} and Chen, \{Shang Hung\} and Chang, \{Jang Yang\}",

year = "2013",

doi = "10.2147/OTT.S33374",

language = "English",

volume = "6",

pages = "1453--1462",

journal = "OncoTargets and Therapy",

issn = "1178-6930",

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T1 - Survivin - biology and potential as a therapeutic target in oncology

AU - Antonio Cheung, Chun Hei

AU - Huang, Chien Chang

AU - Tsai, Fang Ying

AU - Lee, Jane Ying Chieh

AU - Cheng, Siao Muk

AU - Chang, Yung Chieh

AU - Huang, Yi Chun

AU - Chen, Shang Hung

AU - Chang, Jang Yang

PY - 2013

Y1 - 2013

N2 - Survivin is a member of the inhibitor-of-apoptosis proteins (IAPs) family; its overexpression has been widely demonstrated to occur in various types of cancer. Overexpression of survivin also correlates with tumor progression and induces anticancer drug resistance. Interestingly, recent studies reveal that survivin exhibits multiple pro-mitotic and anti-apoptotic functions; the differential functions of survivin seem to be caused by differential subcellular localization, phosphorylation, and acetylation of this molecule. In this review, the complex expression regulations and post-translational modifications of survivin are discussed. This review also discusses how recent discoveries improve our understanding of survivin biology and also create opportunities for developing differential-functioned survivin-targeted therapy. Databases such as PubMed, Scopus® (Elsevier, New York, NY, USA), and SciFinder® (CAS, Columbus, OH, USA) were used to search for literature in the preparation of this review.

AB - Survivin is a member of the inhibitor-of-apoptosis proteins (IAPs) family; its overexpression has been widely demonstrated to occur in various types of cancer. Overexpression of survivin also correlates with tumor progression and induces anticancer drug resistance. Interestingly, recent studies reveal that survivin exhibits multiple pro-mitotic and anti-apoptotic functions; the differential functions of survivin seem to be caused by differential subcellular localization, phosphorylation, and acetylation of this molecule. In this review, the complex expression regulations and post-translational modifications of survivin are discussed. This review also discusses how recent discoveries improve our understanding of survivin biology and also create opportunities for developing differential-functioned survivin-targeted therapy. Databases such as PubMed, Scopus® (Elsevier, New York, NY, USA), and SciFinder® (CAS, Columbus, OH, USA) were used to search for literature in the preparation of this review.

KW - BIRC5

KW - Caspase-9

KW - DIABLO

KW - IAP

KW - Samc

KW - Survivin

KW - XIAP

UR - https://www.scopus.com/pages/publications/84886067499

UR - https://www.scopus.com/pages/publications/84886067499#tab=citedBy

U2 - 10.2147/OTT.S33374

DO - 10.2147/OTT.S33374

M3 - Review article

AN - SCOPUS:84886067499

SN - 1178-6930

VL - 6

SP - 1453

EP - 1462

JO - OncoTargets and Therapy

JF - OncoTargets and Therapy

ER -

Survivin - biology and potential as a therapeutic target in oncology

Abstract

UN SDGs

Keywords

ASJC Scopus subject areas

Access to Document

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