Survival Rates Are Comparable After Radiofrequency Ablation or Surgery in Patients With Small Hepatocellular Carcinomas

Hung Hsu Hung; Yi You Chiou; Cheng Yuan Hsia; Chien Wei Su; Yi Hong Chou; Jen Huey Chiang; Wei Yu Kao; Teh Ia Huo; Yi Hsiang Huang; Yu Hui Su; Han Chieh Lin; Shou Dong Lee; Jaw Ching Wu

doi:10.1016/j.cgh.2010.08.018

Survival Rates Are Comparable After Radiofrequency Ablation or Surgery in Patients With Small Hepatocellular Carcinomas

Hung Hsu Hung, Yi You Chiou, Cheng Yuan Hsia, Chien Wei Su, Yi Hong Chou, Jen Huey Chiang, Wei Yu Kao, Teh Ia Huo, Yi Hsiang Huang, Yu Hui Su, Han Chieh Lin, Shou Dong Lee, Jaw Ching Wu

Research output: Contribution to journal › Article › peer-review

121 Citations (Scopus)

Abstract

Background & Aims: Differences in efficacy of radiofrequency ablation (RFA) and surgical resection (SR) are not clear for patients with hepatocellular carcinoma (HCC). Methods: From 2002 to 2007, 419 patients with HCCs ≤5 cm were enrolled consecutively in the study. Among these patients, 190 and 229 patients received RFA and SR, respectively, as their first treatment. Factors were analyzed in terms of overall survival and recurrence by multivariate analysis and propensity score matching analysis. Results: The SR group had younger age, a higher male-to-female ratio, higher prevalence of hepatitis B virus, lower prevalence of hepatitis C virus, better liver function reserve, and larger tumor size than the RFA group. The cumulative 5-year overall survival rates were 79.3% in the SR group and 67.4% in the RFA group. During the follow-up period, tumors recurred in 244 patients in a median time of 14.5 ± 15.7 months. Before propensity-score matching, the RFA group had shorter overall survival time (P = .009) and higher tumor recurrence rate (P < .001) than the SR group. After matching, RFA was comparable to SR in overall survival time (P = .519), but the RFA group still had a greater incidence of tumor recurrence (P < .001). In patients with Barcelona Clinic Liver Cancer (BCLC) stage 0 HCC, RFA was as effective as SR for overall survival time and recurrence. Conclusions: Patients with small HCCs have a higher rate of tumor recurrence following RFA than surgery, but overall survival rates are comparable between therapies. RFA is as effective as surgery in patients with BCLC stage 0 HCC.

Original language	English
Pages (from-to)	79-86
Number of pages	8
Journal	Clinical Gastroenterology and Hepatology
Volume	9
Issue number	1
DOIs	https://doi.org/10.1016/j.cgh.2010.08.018
Publication status	Published - Jan 1 2011
Externally published	Yes

Keywords

Hepatic
Liver Surgery
Liver Tumor

ASJC Scopus subject areas

Hepatology
Gastroenterology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.cgh.2010.08.018

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Hung, H. H., Chiou, Y. Y., Hsia, C. Y., Su, C. W., Chou, Y. H., Chiang, J. H., Kao, W. Y., Huo, T. I., Huang, Y. H., Su, Y. H., Lin, H. C., Lee, S. D., & Wu, J. C. (2011). Survival Rates Are Comparable After Radiofrequency Ablation or Surgery in Patients With Small Hepatocellular Carcinomas. Clinical Gastroenterology and Hepatology, 9(1), 79-86. https://doi.org/10.1016/j.cgh.2010.08.018

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title = "Survival Rates Are Comparable After Radiofrequency Ablation or Surgery in Patients With Small Hepatocellular Carcinomas",

abstract = "Background & Aims: Differences in efficacy of radiofrequency ablation (RFA) and surgical resection (SR) are not clear for patients with hepatocellular carcinoma (HCC). Methods: From 2002 to 2007, 419 patients with HCCs ≤5 cm were enrolled consecutively in the study. Among these patients, 190 and 229 patients received RFA and SR, respectively, as their first treatment. Factors were analyzed in terms of overall survival and recurrence by multivariate analysis and propensity score matching analysis. Results: The SR group had younger age, a higher male-to-female ratio, higher prevalence of hepatitis B virus, lower prevalence of hepatitis C virus, better liver function reserve, and larger tumor size than the RFA group. The cumulative 5-year overall survival rates were 79.3% in the SR group and 67.4% in the RFA group. During the follow-up period, tumors recurred in 244 patients in a median time of 14.5 ± 15.7 months. Before propensity-score matching, the RFA group had shorter overall survival time (P = .009) and higher tumor recurrence rate (P < .001) than the SR group. After matching, RFA was comparable to SR in overall survival time (P = .519), but the RFA group still had a greater incidence of tumor recurrence (P < .001). In patients with Barcelona Clinic Liver Cancer (BCLC) stage 0 HCC, RFA was as effective as SR for overall survival time and recurrence. Conclusions: Patients with small HCCs have a higher rate of tumor recurrence following RFA than surgery, but overall survival rates are comparable between therapies. RFA is as effective as surgery in patients with BCLC stage 0 HCC.",

keywords = "Hepatic, Liver Surgery, Liver Tumor",

author = "Hung, {Hung Hsu} and Chiou, {Yi You} and Hsia, {Cheng Yuan} and Su, {Chien Wei} and Chou, {Yi Hong} and Chiang, {Jen Huey} and Kao, {Wei Yu} and Huo, {Teh Ia} and Huang, {Yi Hsiang} and Su, {Yu Hui} and Lin, {Han Chieh} and Lee, {Shou Dong} and Wu, {Jaw Ching}",

year = "2011",

month = jan,

day = "1",

doi = "10.1016/j.cgh.2010.08.018",

language = "English",

volume = "9",

pages = "79--86",

journal = "Clinical Gastroenterology and Hepatology",

issn = "1542-3565",

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TY - JOUR

T1 - Survival Rates Are Comparable After Radiofrequency Ablation or Surgery in Patients With Small Hepatocellular Carcinomas

AU - Hung, Hung Hsu

AU - Chiou, Yi You

AU - Hsia, Cheng Yuan

AU - Su, Chien Wei

AU - Chou, Yi Hong

AU - Chiang, Jen Huey

AU - Kao, Wei Yu

AU - Huo, Teh Ia

AU - Huang, Yi Hsiang

AU - Su, Yu Hui

AU - Lin, Han Chieh

AU - Lee, Shou Dong

AU - Wu, Jaw Ching

PY - 2011/1/1

Y1 - 2011/1/1

N2 - Background & Aims: Differences in efficacy of radiofrequency ablation (RFA) and surgical resection (SR) are not clear for patients with hepatocellular carcinoma (HCC). Methods: From 2002 to 2007, 419 patients with HCCs ≤5 cm were enrolled consecutively in the study. Among these patients, 190 and 229 patients received RFA and SR, respectively, as their first treatment. Factors were analyzed in terms of overall survival and recurrence by multivariate analysis and propensity score matching analysis. Results: The SR group had younger age, a higher male-to-female ratio, higher prevalence of hepatitis B virus, lower prevalence of hepatitis C virus, better liver function reserve, and larger tumor size than the RFA group. The cumulative 5-year overall survival rates were 79.3% in the SR group and 67.4% in the RFA group. During the follow-up period, tumors recurred in 244 patients in a median time of 14.5 ± 15.7 months. Before propensity-score matching, the RFA group had shorter overall survival time (P = .009) and higher tumor recurrence rate (P < .001) than the SR group. After matching, RFA was comparable to SR in overall survival time (P = .519), but the RFA group still had a greater incidence of tumor recurrence (P < .001). In patients with Barcelona Clinic Liver Cancer (BCLC) stage 0 HCC, RFA was as effective as SR for overall survival time and recurrence. Conclusions: Patients with small HCCs have a higher rate of tumor recurrence following RFA than surgery, but overall survival rates are comparable between therapies. RFA is as effective as surgery in patients with BCLC stage 0 HCC.

AB - Background & Aims: Differences in efficacy of radiofrequency ablation (RFA) and surgical resection (SR) are not clear for patients with hepatocellular carcinoma (HCC). Methods: From 2002 to 2007, 419 patients with HCCs ≤5 cm were enrolled consecutively in the study. Among these patients, 190 and 229 patients received RFA and SR, respectively, as their first treatment. Factors were analyzed in terms of overall survival and recurrence by multivariate analysis and propensity score matching analysis. Results: The SR group had younger age, a higher male-to-female ratio, higher prevalence of hepatitis B virus, lower prevalence of hepatitis C virus, better liver function reserve, and larger tumor size than the RFA group. The cumulative 5-year overall survival rates were 79.3% in the SR group and 67.4% in the RFA group. During the follow-up period, tumors recurred in 244 patients in a median time of 14.5 ± 15.7 months. Before propensity-score matching, the RFA group had shorter overall survival time (P = .009) and higher tumor recurrence rate (P < .001) than the SR group. After matching, RFA was comparable to SR in overall survival time (P = .519), but the RFA group still had a greater incidence of tumor recurrence (P < .001). In patients with Barcelona Clinic Liver Cancer (BCLC) stage 0 HCC, RFA was as effective as SR for overall survival time and recurrence. Conclusions: Patients with small HCCs have a higher rate of tumor recurrence following RFA than surgery, but overall survival rates are comparable between therapies. RFA is as effective as surgery in patients with BCLC stage 0 HCC.

KW - Hepatic

KW - Liver Surgery

KW - Liver Tumor

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U2 - 10.1016/j.cgh.2010.08.018

DO - 10.1016/j.cgh.2010.08.018

M3 - Article

C2 - 20831902

AN - SCOPUS:78650237768

SN - 1542-3565

VL - 9

SP - 79

EP - 86

JO - Clinical Gastroenterology and Hepatology

JF - Clinical Gastroenterology and Hepatology

IS - 1

ER -

Survival Rates Are Comparable After Radiofrequency Ablation or Surgery in Patients With Small Hepatocellular Carcinomas

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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