Survival of Cancer Cells Is Maintained by EGFR Independent of Its Kinase Activity

Zhang Weihua; Rachel Tsan; Wei Chien Huang; Qiuyu Wu; Chao Hua Chiu; Isaiah J. Fidler; Mien Chie Hung

doi:10.1016/j.ccr.2008.03.015

Survival of Cancer Cells Is Maintained by EGFR Independent of Its Kinase Activity

Zhang Weihua, Rachel Tsan, Wei Chien Huang, Qiuyu Wu, Chao Hua Chiu, Isaiah J. Fidler, Mien Chie Hung

Research output: Contribution to journal › Article › peer-review

433 Citations (Scopus)

Abstract

Expression of the epidermal growth factor receptor (EGFR), a receptor tyrosine kinase associated with cell proliferation and survival, is overactive in many tumors of epithelial origin. Blockade of the kinase activity of EGFR has been used for cancer therapy; however, by itself, it does not seem to reach maximum therapeutic efficacy. We report here that in human cancer cells, the function of kinase-independent EGFR is to prevent autophagic cell death by maintaining intracellular glucose level through interaction and stabilization of the sodium/glucose cotransporter 1 (SGLT1).

Original language	English
Pages (from-to)	385-393
Number of pages	9
Journal	Cancer Cell
Volume	13
Issue number	5
DOIs	https://doi.org/10.1016/j.ccr.2008.03.015
Publication status	Published - May 2008
Externally published	Yes

Keywords

CELLBIO
CELLCYCLE

ASJC Scopus subject areas

Oncology
Cell Biology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.ccr.2008.03.015

Cite this

@article{932b2e9e4c2e45679458774759d2a7d8,

title = "Survival of Cancer Cells Is Maintained by EGFR Independent of Its Kinase Activity",

abstract = "Expression of the epidermal growth factor receptor (EGFR), a receptor tyrosine kinase associated with cell proliferation and survival, is overactive in many tumors of epithelial origin. Blockade of the kinase activity of EGFR has been used for cancer therapy; however, by itself, it does not seem to reach maximum therapeutic efficacy. We report here that in human cancer cells, the function of kinase-independent EGFR is to prevent autophagic cell death by maintaining intracellular glucose level through interaction and stabilization of the sodium/glucose cotransporter 1 (SGLT1).",

keywords = "CELLBIO, CELLCYCLE",

author = "Zhang Weihua and Rachel Tsan and Huang, {Wei Chien} and Qiuyu Wu and Chiu, {Chao Hua} and Fidler, {Isaiah J.} and Hung, {Mien Chie}",

note = "Funding Information: This work was supported in part by SPORE in Prostate Cancer CA-90270 (to I.J.F.), SPORE in Breast Cancer CA-116199 (to M-C. Hung) and Cancer Center Support Core grant CA-16672, National Cancer Institute, National Institutes of Health. Z.W. was partially supported by an Odyssey Fellowship Award from The University of Texas M.D. Anderson Cancer Center. We thank David Zhiwei He and Karen Ramirez for excellent technical support. ",

year = "2008",

month = may,

doi = "10.1016/j.ccr.2008.03.015",

language = "English",

volume = "13",

pages = "385--393",

journal = "Cancer Cell",

issn = "1535-6108",

publisher = "Cell Press",

number = "5",

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TY - JOUR

T1 - Survival of Cancer Cells Is Maintained by EGFR Independent of Its Kinase Activity

AU - Weihua, Zhang

AU - Tsan, Rachel

AU - Huang, Wei Chien

AU - Wu, Qiuyu

AU - Chiu, Chao Hua

AU - Fidler, Isaiah J.

AU - Hung, Mien Chie

N1 - Funding Information: This work was supported in part by SPORE in Prostate Cancer CA-90270 (to I.J.F.), SPORE in Breast Cancer CA-116199 (to M-C. Hung) and Cancer Center Support Core grant CA-16672, National Cancer Institute, National Institutes of Health. Z.W. was partially supported by an Odyssey Fellowship Award from The University of Texas M.D. Anderson Cancer Center. We thank David Zhiwei He and Karen Ramirez for excellent technical support.

PY - 2008/5

Y1 - 2008/5

N2 - Expression of the epidermal growth factor receptor (EGFR), a receptor tyrosine kinase associated with cell proliferation and survival, is overactive in many tumors of epithelial origin. Blockade of the kinase activity of EGFR has been used for cancer therapy; however, by itself, it does not seem to reach maximum therapeutic efficacy. We report here that in human cancer cells, the function of kinase-independent EGFR is to prevent autophagic cell death by maintaining intracellular glucose level through interaction and stabilization of the sodium/glucose cotransporter 1 (SGLT1).

AB - Expression of the epidermal growth factor receptor (EGFR), a receptor tyrosine kinase associated with cell proliferation and survival, is overactive in many tumors of epithelial origin. Blockade of the kinase activity of EGFR has been used for cancer therapy; however, by itself, it does not seem to reach maximum therapeutic efficacy. We report here that in human cancer cells, the function of kinase-independent EGFR is to prevent autophagic cell death by maintaining intracellular glucose level through interaction and stabilization of the sodium/glucose cotransporter 1 (SGLT1).

KW - CELLBIO

KW - CELLCYCLE

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DO - 10.1016/j.ccr.2008.03.015

M3 - Article

C2 - 18455122

AN - SCOPUS:42949176742

SN - 1535-6108

VL - 13

SP - 385

EP - 393

JO - Cancer Cell

JF - Cancer Cell

IS - 5

ER -

Survival of Cancer Cells Is Maintained by EGFR Independent of Its Kinase Activity

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

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