Surgical outcome predictor analysis following hand-assisted or pure laparoscopic transperitoneal nephroureterectomy using the Taiwan upper urinary tract urothelial carcinoma database

Chih Chun Kuo, Guang Heng Chen, Chao Hsiang Chang, Chao Yuan Huang, Chung Hsin Chen, Ching Chia Li, Wen Jeng Wu, Chih Chin Yu, Chi Wen Lo, Yung Tai Chen, Shin Hong Chen, Pai Yu Cheng, Thomas Y Hsueh, Allen W. Chiu, Po Han Lin, Jen Shu Tseng, Jen Tai Lin, Yuan Hong Jiang, Chia Chang Wu, Wei Yu LinHsu Che Huang, Han Sun Chiang, Bing Juin Chiang

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

Purpose: Taiwan has a high incidence of upper tract urothelial carcinoma (UTUC). This study aimed to compare the surgical outcomes following transperitoneal hand-assisted laparoscopic nephroureterectomy (TP-HALNU) and transperitoneal pure laparoscopic nephroureterectomy (TP-LNU) from the Taiwan nationwide UTUC collaboration database using different parameters, including surgical volumes. Materials and methods: The nationwide UTUC collaboration database includes 14 hospitals in Taiwan from the Taiwan Cancer Registry. We retrospectively reviewed the records of 622 patients who underwent laparoscopic nephroureterectomy between July 1988 and September 2020. In total, 322 patients who received TP-LNU or TP-HALNU were included in the final analysis. Clinical and pathological data and oncological outcomes were compared. Results: Of the 322 patients, 181 and 141 received TP-LNU and TP-HALNU, respectively. There were no differences in clinical and histopathological data between the two groups. No differences were observed in perioperative and postoperative complications. There were no significant differences in oncological outcomes between the two surgical approaches. In the multivariate analysis, the cohort showed that age ≥70 years, positive pathological lymph node metastasis, tumors located in the upper ureter, and male sex were predictive factors associated with an increased risk of adverse oncological outcomes. A surgical volume of ≥20 cases showed a trend toward favorable outcomes on cancer-specific survival [hazard ratio (HR) 0.154, p = 0.052] and marginal benefit for overall survival (HR 0.326, p = 0.019) in the multivariate analysis. Conclusion: Although different approaches to transperitoneal laparoscopic nephroureterectomy showed no significant differences in surgical outcomes, age, sex, lymph node metastasis, and tumor in the upper ureter in the following period were predictive factors for oncological outcomes. Higher surgical volume did not impact disease-free survival and bladder recurrence-free survival but was associated with improved overall survival and cancer-specific survival. Exploration of unknown influencing factors is warranted.

Original languageEnglish
Article number934355
JournalFrontiers in Surgery
Volume9
DOIs
Publication statusPublished - Sept 2022

Keywords

  • hand-assisted laparoscopic nephroureterectomy
  • laparoscopic nephroureterectomy
  • oncological outcome
  • surgical volume
  • upper urinary tract urothelial carcinoma
  • urothelial carcinoma

ASJC Scopus subject areas

  • Surgery

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