Surface nanotopography of an anodized Ti-6Al-7Nb alloy enhances cell growth

Her Hsiung Huang, Chia Ping Wu, Ying Sui Sun, Wei En Yang, Tzu Hsin Lee

Research output: Contribution to journalArticlepeer-review

27 Citations (Scopus)


The α/β-type Ti-6Al-7Nb alloy is a potential replacement for α/β-type Ti-6Al-4V alloy, which is widely used in biomedical implant applications. The biological response to implant material is dependent on the surface characteristics of the material. In the present study, a simple and fast process was developed to perform an electrochemical anodization treatment on Ti-6Al-7Nb alloy. The proposed process yielded a thin surface nanotopography, which enhanced cell growth on the Ti-6Al-7Nb alloy. The surface characteristics, including the morphology, wettability, and protein adsorption, were investigated, and the cytotoxicity was evaluated according to International Organization for Standardization 10993-5 specifications. Cell adhesion of human bone marrow mesenchymal stem cells on the test specimens was observed via fluorescence microscopy and scanning electron microscopy. The anodization process produced a surface nanotopography (pore size <100 nm) on anodized Ti-6Al-7Nb alloy, which enhanced the wettability, protein adsorption, cell adhesion, cell migration, and cell mineralization. The results showed that the surface nanotopography produced using the proposed electrochemical anodization process enhanced cell growth on anodized Ti-6Al-7Nb alloy for implant applications.

Original languageEnglish
Pages (from-to)S648-S654
JournalJournal of Alloys and Compounds
Issue numberS1
Publication statusPublished - Dec 5 2014


  • Cell growth
  • Electrochemical anodization
  • Surface nanotopography
  • Ti-6Al-7Nb alloy

ASJC Scopus subject areas

  • Mechanics of Materials
  • Mechanical Engineering
  • Metals and Alloys
  • Materials Chemistry


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