Surface nanoporosity of β-type Ti-25Nb-25Zr alloy for the enhancement of protein adsorption and cell response

Her Hsiung Huang; Chia Ping Wu; Ying Sui Sun; Wei En Yang; Mau Chin Lin; Tzu Hsin Lee

doi:10.1016/j.surfcoat.2014.02.037

Surface nanoporosity of β-type Ti-25Nb-25Zr alloy for the enhancement of protein adsorption and cell response

Her Hsiung Huang, Chia Ping Wu, Ying Sui Sun, Wei En Yang, Mau Chin Lin, Tzu Hsin Lee

School of Dental Technology

Research output: Contribution to journal › Article › peer-review

29 Citations (Scopus)

Abstract

This paper outlines a simple method for the electrochemical anodization of β-type Ti-25Nb-25Zr (Ti25Nb25Zr) alloy with a low elastic modulus (approximately 70. GPa) to alter its surface topography for bone implant applications. Surface characteristics including topography, roughness, hydrophilicity, and protein adsorption (fibronectin and albumin) were investigated. Human bone marrow mesenchymal stem cell responses, including adhesion, migration, proliferation, and mineralization, were also evaluated. The experimental results demonstrate that the electrochemical anodization process produced a nanoporous surface (pore size <. 15. nm) on Ti25Nb25Zr alloy. This surface nanotopography did not alter the surface roughness or hydrophilicity of the Ti25Nb25Zr alloy but was capable of enhancing biological responses, including protein adsorption, cell adhesion, cell migration, cell proliferation, and cell mineralization. The created surface nanoporosity on β-type Ti25Nb25Zr alloy has a high potential for bone implant applications.

Original language	English
Pages (from-to)	206-212
Number of pages	7
Journal	Surface and Coatings Technology
Volume	259
Issue number	PB
DOIs	https://doi.org/10.1016/j.surfcoat.2014.02.037
Publication status	Published - Jan 1 2014

Keywords

Cell response
Electrochemical anodization
Protein adsorption
Surface nanoporosity
Ti-25Nb-25Zr alloy

ASJC Scopus subject areas

General Chemistry
Condensed Matter Physics
Surfaces and Interfaces
Surfaces, Coatings and Films
Materials Chemistry

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10.1016/j.surfcoat.2014.02.037

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title = "Surface nanoporosity of β-type Ti-25Nb-25Zr alloy for the enhancement of protein adsorption and cell response",

abstract = "This paper outlines a simple method for the electrochemical anodization of β-type Ti-25Nb-25Zr (Ti25Nb25Zr) alloy with a low elastic modulus (approximately 70. GPa) to alter its surface topography for bone implant applications. Surface characteristics including topography, roughness, hydrophilicity, and protein adsorption (fibronectin and albumin) were investigated. Human bone marrow mesenchymal stem cell responses, including adhesion, migration, proliferation, and mineralization, were also evaluated. The experimental results demonstrate that the electrochemical anodization process produced a nanoporous surface (pore size <. 15. nm) on Ti25Nb25Zr alloy. This surface nanotopography did not alter the surface roughness or hydrophilicity of the Ti25Nb25Zr alloy but was capable of enhancing biological responses, including protein adsorption, cell adhesion, cell migration, cell proliferation, and cell mineralization. The created surface nanoporosity on β-type Ti25Nb25Zr alloy has a high potential for bone implant applications.",

keywords = "Cell response, Electrochemical anodization, Protein adsorption, Surface nanoporosity, Ti-25Nb-25Zr alloy",

author = "Huang, {Her Hsiung} and Wu, {Chia Ping} and Sun, {Ying Sui} and Yang, {Wei En} and Lin, {Mau Chin} and Lee, {Tzu Hsin}",

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year = "2014",

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doi = "10.1016/j.surfcoat.2014.02.037",

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T1 - Surface nanoporosity of β-type Ti-25Nb-25Zr alloy for the enhancement of protein adsorption and cell response

AU - Huang, Her Hsiung

AU - Wu, Chia Ping

AU - Sun, Ying Sui

AU - Yang, Wei En

AU - Lin, Mau Chin

AU - Lee, Tzu Hsin

PY - 2014/1/1

Y1 - 2014/1/1

N2 - This paper outlines a simple method for the electrochemical anodization of β-type Ti-25Nb-25Zr (Ti25Nb25Zr) alloy with a low elastic modulus (approximately 70. GPa) to alter its surface topography for bone implant applications. Surface characteristics including topography, roughness, hydrophilicity, and protein adsorption (fibronectin and albumin) were investigated. Human bone marrow mesenchymal stem cell responses, including adhesion, migration, proliferation, and mineralization, were also evaluated. The experimental results demonstrate that the electrochemical anodization process produced a nanoporous surface (pore size <. 15. nm) on Ti25Nb25Zr alloy. This surface nanotopography did not alter the surface roughness or hydrophilicity of the Ti25Nb25Zr alloy but was capable of enhancing biological responses, including protein adsorption, cell adhesion, cell migration, cell proliferation, and cell mineralization. The created surface nanoporosity on β-type Ti25Nb25Zr alloy has a high potential for bone implant applications.

AB - This paper outlines a simple method for the electrochemical anodization of β-type Ti-25Nb-25Zr (Ti25Nb25Zr) alloy with a low elastic modulus (approximately 70. GPa) to alter its surface topography for bone implant applications. Surface characteristics including topography, roughness, hydrophilicity, and protein adsorption (fibronectin and albumin) were investigated. Human bone marrow mesenchymal stem cell responses, including adhesion, migration, proliferation, and mineralization, were also evaluated. The experimental results demonstrate that the electrochemical anodization process produced a nanoporous surface (pore size <. 15. nm) on Ti25Nb25Zr alloy. This surface nanotopography did not alter the surface roughness or hydrophilicity of the Ti25Nb25Zr alloy but was capable of enhancing biological responses, including protein adsorption, cell adhesion, cell migration, cell proliferation, and cell mineralization. The created surface nanoporosity on β-type Ti25Nb25Zr alloy has a high potential for bone implant applications.

KW - Cell response

KW - Electrochemical anodization

KW - Protein adsorption

KW - Surface nanoporosity

KW - Ti-25Nb-25Zr alloy

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Surface nanoporosity of β-type Ti-25Nb-25Zr alloy for the enhancement of protein adsorption and cell response

Abstract

Keywords

ASJC Scopus subject areas

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