SUMOylation of Blimp-1 is critical for plasma cell differentiation

Hsia Yuan Ying; Shin Tang Su; Pang Hung Hsu; Che Chang Chang; I. Ying Lin; Yu Hsuan Tseng; Ming Daw Tsai; Hsiu Ming Shih; Kuo I. Lin

doi:10.1038/embor.2012.60

SUMOylation of Blimp-1 is critical for plasma cell differentiation

Hsia Yuan Ying
, Shin Tang Su
, Pang Hung Hsu
, Che Chang Chang
, I. Ying Lin
, Yu Hsuan Tseng
, Ming Daw Tsai
, Hsiu Ming Shih
, Kuo I. Lin

Research output: Contribution to journal › Article › peer-review

20 Citations (Scopus)

Abstract

Transcriptional repressor B lymphocyte-induced maturation protein-1 (Blimp-1) is a master regulator of plasma cell differentiation. Here we show that Blimp-1 is covalently modified by SUMO1 at lysine 816, a modification mediated by SUMO E3 ligase PIAS1. Mutation of Blimp-1 lysine 816 reduces transcriptional repression-correlating with a reduced interaction with a histone deacetylase, HDAC2-and impairs differentiation of antibody-secreting cells. Thus, the SUMO pathway critically regulates Blimp-1 function during plasma cell differentiation.

Original language	English
Pages (from-to)	631-637
Number of pages	7
Journal	EMBO Reports
Volume	13
Issue number	7
DOIs	https://doi.org/10.1038/embor.2012.60
Publication status	Published - Jul 2012
Externally published	Yes

Keywords

SUMO
differentiation
plasma cell
transcriptional repression

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Genetics

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10.1038/embor.2012.60

Cite this

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AU - Su, Shin Tang

AU - Hsu, Pang Hung

AU - Chang, Che Chang

AU - Lin, I. Ying

AU - Tseng, Yu Hsuan

AU - Tsai, Ming Daw

AU - Shih, Hsiu Ming

AU - Lin, Kuo I.

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AB - Transcriptional repressor B lymphocyte-induced maturation protein-1 (Blimp-1) is a master regulator of plasma cell differentiation. Here we show that Blimp-1 is covalently modified by SUMO1 at lysine 816, a modification mediated by SUMO E3 ligase PIAS1. Mutation of Blimp-1 lysine 816 reduces transcriptional repression-correlating with a reduced interaction with a histone deacetylase, HDAC2-and impairs differentiation of antibody-secreting cells. Thus, the SUMO pathway critically regulates Blimp-1 function during plasma cell differentiation.

KW - SUMO

KW - differentiation

KW - plasma cell

KW - transcriptional repression

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SUMOylation of Blimp-1 is critical for plasma cell differentiation

Abstract

Keywords

ASJC Scopus subject areas

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