Abstract
Transcriptional repressor B lymphocyte-induced maturation protein-1 (Blimp-1) is a master regulator of plasma cell differentiation. Here we show that Blimp-1 is covalently modified by SUMO1 at lysine 816, a modification mediated by SUMO E3 ligase PIAS1. Mutation of Blimp-1 lysine 816 reduces transcriptional repression-correlating with a reduced interaction with a histone deacetylase, HDAC2-and impairs differentiation of antibody-secreting cells. Thus, the SUMO pathway critically regulates Blimp-1 function during plasma cell differentiation.
Original language | English |
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Pages (from-to) | 631-637 |
Number of pages | 7 |
Journal | EMBO Reports |
Volume | 13 |
Issue number | 7 |
DOIs | |
Publication status | Published - Jul 2012 |
Externally published | Yes |
Keywords
- differentiation
- plasma cell
- SUMO
- transcriptional repression
ASJC Scopus subject areas
- Genetics
- Molecular Biology
- Biochemistry