SUMOylation of Blimp-1 is critical for plasma cell differentiation

Hsia Yuan Ying; Shin Tang Su; Pang Hung Hsu; Che Chang Chang; I. Ying Lin; Yu Hsuan Tseng; Ming Daw Tsai; Hsiu Ming Shih; Kuo I. Lin

doi:10.1038/embor.2012.60

SUMOylation of Blimp-1 is critical for plasma cell differentiation

Hsia Yuan Ying, Shin Tang Su, Pang Hung Hsu, Che Chang Chang, I. Ying Lin, Yu Hsuan Tseng, Ming Daw Tsai, Hsiu Ming Shih, Kuo I. Lin

Research output: Contribution to journal › Article › peer-review

17 Citations (Scopus)

Abstract

Transcriptional repressor B lymphocyte-induced maturation protein-1 (Blimp-1) is a master regulator of plasma cell differentiation. Here we show that Blimp-1 is covalently modified by SUMO1 at lysine 816, a modification mediated by SUMO E3 ligase PIAS1. Mutation of Blimp-1 lysine 816 reduces transcriptional repression-correlating with a reduced interaction with a histone deacetylase, HDAC2-and impairs differentiation of antibody-secreting cells. Thus, the SUMO pathway critically regulates Blimp-1 function during plasma cell differentiation.

Original language	English
Pages (from-to)	631-637
Number of pages	7
Journal	EMBO Reports
Volume	13
Issue number	7
DOIs	https://doi.org/10.1038/embor.2012.60
Publication status	Published - Jul 2012
Externally published	Yes

Keywords

differentiation
plasma cell
SUMO
transcriptional repression

ASJC Scopus subject areas

Genetics
Molecular Biology
Biochemistry

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10.1038/embor.2012.60

Cite this

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abstract = "Transcriptional repressor B lymphocyte-induced maturation protein-1 (Blimp-1) is a master regulator of plasma cell differentiation. Here we show that Blimp-1 is covalently modified by SUMO1 at lysine 816, a modification mediated by SUMO E3 ligase PIAS1. Mutation of Blimp-1 lysine 816 reduces transcriptional repression-correlating with a reduced interaction with a histone deacetylase, HDAC2-and impairs differentiation of antibody-secreting cells. Thus, the SUMO pathway critically regulates Blimp-1 function during plasma cell differentiation.",

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AU - Ying, Hsia Yuan

AU - Su, Shin Tang

AU - Hsu, Pang Hung

AU - Chang, Che Chang

AU - Lin, I. Ying

AU - Tseng, Yu Hsuan

AU - Tsai, Ming Daw

AU - Shih, Hsiu Ming

AU - Lin, Kuo I.

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AB - Transcriptional repressor B lymphocyte-induced maturation protein-1 (Blimp-1) is a master regulator of plasma cell differentiation. Here we show that Blimp-1 is covalently modified by SUMO1 at lysine 816, a modification mediated by SUMO E3 ligase PIAS1. Mutation of Blimp-1 lysine 816 reduces transcriptional repression-correlating with a reduced interaction with a histone deacetylase, HDAC2-and impairs differentiation of antibody-secreting cells. Thus, the SUMO pathway critically regulates Blimp-1 function during plasma cell differentiation.

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KW - transcriptional repression

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SUMOylation of Blimp-1 is critical for plasma cell differentiation

Abstract

Keywords

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