Abstract
Melioidosis is an endemic disease in southeast Asia and northern Australia, caused by Burkholderia pseudomallei. A typhoon-related outbreak occurred in southern Taiwan in July 2005. High mortality in melioidosis associated with bacteremic pneumonia and septic shock. We report a patient with life-threatening melioidosis who developed rapid progression of bacteremic pneumonia with acute respiratory distress syndrome, septic shock and multiple organ dysfunction and was successfully treated with recombinant human activated protein C (rhAPC) and meropenem. Although rhAPC has been reported to reduce the mortality of severe septic shock caused by various pathogens, to our best knowledge, this is the first reported case of rhAPC application in life-threatening melioidosis.
| Original language | English |
|---|---|
| Pages (from-to) | 83-87 |
| Number of pages | 5 |
| Journal | Journal of Microbiology, Immunology and Infection |
| Volume | 40 |
| Issue number | 1 |
| Publication status | Published - Feb 2007 |
| Externally published | Yes |
Keywords
- Burkholderia pseudomallei
- Melioidosis
- Pneumonia
- Recombinant proteins
- Respiratory distress syndrome, adult
- Shock, septic
- Thienamycins
ASJC Scopus subject areas
- General Immunology and Microbiology
- Microbiology (medical)
- Infectious Diseases
- Immunology and Allergy
