Abstract
We report two patients with drug-induced liver injury (DILI)-related acute liver failure (ALF) who were successfully treated with high-volume plasma exchange without liver transplantation. The first patient was a 66-year-old man admitted because of a perforated duodenal ulcer complicated with peritonitis and septic shock. After treatment with multiple antibiotics, the patient developed DILI and ALF. Grade 3 hepatic encephalopathy and profound jaundice were present. Symptoms and signs of ALF improved dramatically after initiation of plasma exchange. The patient was discharged uneventfully. The second patient was a 94-year-old man admitted for treatment of newly diagnosed pulmonary tuberculosis. DILI and ALF developed 5 days after initiation of anti-tuberculosis treatment. Grade 4 hepatic encephalopathy was present. After plasma exchange, the patient's level of consciousness improved dramatically, and he recovered from ALF. These 2 cases show the potential of plasma exchange in the treatment of DILI despite occurrence acute liver failure. J. Clin. Apheresis, 28:430-434, 2013.
Original language | English |
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Pages (from-to) | 430-434 |
Number of pages | 5 |
Journal | Journal of Clinical Apheresis |
Volume | 28 |
Issue number | 6 |
DOIs | |
Publication status | Published - Dec 2013 |
Keywords
- acute liver failure
- artificial liver support
- drug-induced liver injury
- plasma exchange
ASJC Scopus subject areas
- Hematology