Successful treatment of an extensive verrucous carcinoma with topical 5-aminolevulinic acid-mediated photodynamic therapy

Hsin Ming Chen; Chin Tin Chen; Hsiang Yang; Ming I. Lee; Mark Yen Ping Kuo; Ying Shiung Kuo; Yi Ping Wang; Tsuimin Tsai; Chun Pin Chiang

doi:10.1111/j.1600-0714.2004.00267.x

Successful treatment of an extensive verrucous carcinoma with topical 5-aminolevulinic acid-mediated photodynamic therapy

Hsin Ming Chen, Chin Tin Chen, Hsiang Yang, Ming I. Lee, Mark Yen Ping Kuo, Ying Shiung Kuo, Yi Ping Wang, Tsuimin Tsai, Chun Pin Chiang

Graduate Institute of Biomedical Materials and Tissue Engineering

Research output: Contribution to journal › Article › peer-review

53 Citations (Scopus)

Abstract

Our recent study found that a new topical 5-aminolevulinic acid-mediated photodynamic therapy (ALA-PDT) protocol composed of multiple 3-min fractionated irradiations with a light emitting diode (LED) red light at 635 ± 5 nm for a total of 1000 s (fluence rate: 100 mW/cm²; light exposure dose: 100 J/cm²) after topical application of 20% ALA for 1.5 or 2 h can be used successfully for the treatment of oral verrucous hyperplasia. In this case report, we tested the efficacy of this new treatment protocol of ALA-PDT for an extraoral verrucous carcinoma (VC) lesion at the right mouth angle and an intraoral VC lesion at the right buccal mucosa of a 56-year-old male areca quid chewer and smoker. The extraoral tumor was cleared after six treatments of topical ALA-PDT and the intraoral tumor showed complete regression after 22 treatments of topical ALA-PDT. No recurrence of the VC lesion was found after a follow-up period of 6 months. We suggest that FDT using a topical application of 20% ALA followed by multiple 3-min fractionated irradiations with an LED red light is also an effective and successful treatment modality for VC.

Original language	English
Pages (from-to)	253-256
Number of pages	4
Journal	Journal of Oral Pathology and Medicine
Volume	34
Issue number	4
DOIs	https://doi.org/10.1111/j.1600-0714.2004.00267.x
Publication status	Published - Apr 2005

Keywords

5-aminolevulinic acid
Photodynamic therapy
Verrucous carcinoma

ASJC Scopus subject areas

Oral Surgery
Periodontics
Cancer Research
Pathology and Forensic Medicine
Otorhinolaryngology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1111/j.1600-0714.2004.00267.x

Cite this

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title = "Successful treatment of an extensive verrucous carcinoma with topical 5-aminolevulinic acid-mediated photodynamic therapy",

abstract = "Our recent study found that a new topical 5-aminolevulinic acid-mediated photodynamic therapy (ALA-PDT) protocol composed of multiple 3-min fractionated irradiations with a light emitting diode (LED) red light at 635 ± 5 nm for a total of 1000 s (fluence rate: 100 mW/cm2; light exposure dose: 100 J/cm2) after topical application of 20% ALA for 1.5 or 2 h can be used successfully for the treatment of oral verrucous hyperplasia. In this case report, we tested the efficacy of this new treatment protocol of ALA-PDT for an extraoral verrucous carcinoma (VC) lesion at the right mouth angle and an intraoral VC lesion at the right buccal mucosa of a 56-year-old male areca quid chewer and smoker. The extraoral tumor was cleared after six treatments of topical ALA-PDT and the intraoral tumor showed complete regression after 22 treatments of topical ALA-PDT. No recurrence of the VC lesion was found after a follow-up period of 6 months. We suggest that FDT using a topical application of 20% ALA followed by multiple 3-min fractionated irradiations with an LED red light is also an effective and successful treatment modality for VC.",

keywords = "5-aminolevulinic acid, Photodynamic therapy, Verrucous carcinoma",

author = "Chen, {Hsin Ming} and Chen, {Chin Tin} and Hsiang Yang and Lee, {Ming I.} and Kuo, {Mark Yen Ping} and Kuo, {Ying Shiung} and Wang, {Yi Ping} and Tsuimin Tsai and Chiang, {Chun Pin}",

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Successful treatment of an extensive verrucous carcinoma with topical 5-aminolevulinic acid-mediated photodynamic therapy

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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